1.00247

クエン酸

anhydrous fine-granular, EMPROVE^® ESSENTIAL, Ph. Eur., BP, ChP, JP, USP, FCC, E 330

• 別名: 2-Hydroxypropane-1,2,3-tricarboxylic acid, Hydroxytricarballylic acid
• 化学式: HOC(COOH)(CH₂COOH)₂
• CAS番号: 77-92-9
• 分子量: 192.12
• Beilstein: 782061
• MDL番号: MFCD00011669
• UNSPSCコード: 12352106
• E番号: E330
• EC Index Number: 201-069-1

特性

• 認証: BP; ChP; JP; Ph. Eur.; USP
• 品質水準: 500
• 法規制遵守: FCC
• 蒸気圧: <0.1 hPa ( 20 °C)
• 製品種目: EMPROVE^® ESSENTIAL
• アッセイ: 99.5-100.5% substance (anhydrous) basis (alkalimetric)
• 形状: coarse powder
• 有効性: 3000 mg/kg LD₅₀, oral (Rat)
• expl. lim.: 8 %, 65 °F
• pH: 1.7 (20 °C, 100 g/L in H₂O)
• pKa: (1) 3.13, (2) 4.76, (3) 6.4
• bp: 200 °C/1013 hPa (decomposition)
• mp: 153-159 °C (lit.)
• 溶解性: water: 1330 g/L at 20 °C
• 密度: 1.665 g/cm³ at 18 °C
• 微量陽イオン: Al: ≤0.2 ppm; As: ≤1 ppm; Hg: ≤1 ppm; Pb: ≤0.5 ppm; heavy metals (as Pb): ≤5 ppm
• アプリケーション: liquid formulation; ophthalmics; pharmaceutical; semi-solid formulation; solid formulation
• 保管温度: 2-30°C
• SMILES記法: OC(=O)CC(O)(CC(O)=O)C(O)=O
• InChI: 1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
• InChI Key: KRKNYBCHXYNGOX-UHFFFAOYSA-N

詳細

詳細

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

アプリケーション

Citric acid is typically used as pH adjuster, buffer agent or as antioxidant in pharmaceutical formulations. Its application range spans across different formulation types, including semi-solid dosage forms, liquid dosage forms such as solutions and solid dosage forms such as effervescent tablets or granules.
Citric acid anhydrous powder Emprove^® Essential is citric acid present in its water-free, fine granulated form.

法的情報

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable