P7769

1,2-Diacyl-sn-glycero-3-phospho-L-serine

from bovine brain, ≥97% (TLC), amorphous powder, structural phospholipid

• Sinonimo/i: 3-sn-Phosphatidyl-L-serine, L-α-Phosphatidyl-L-serine, PS, Phosphatidylserine
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Nome del prodotto: 1,2-Diacyl-sn-glycero-3-phospho-L-serine, ≥97% (TLC), from bovine brain, amorphous powder
• Origine biologica: bovine brain
• Livello qualitativo: 200
• Saggio: ≥97% (TLC)
• Stato: amorphous powder
• Temperatura di conservazione: −20°C

Descrizione

Applicazioni

1,2-Diacyl-sn-glycero-3-phospho-L-serine has been used:

• as a lipid standard in time-of-flight secondary ion mass spectrometry (ToF-SIMS) spectral fingerprints[1]
• as a reference standard in thin layer chromatography (TLC) for quantifying lipids from astrocyte-conditioned media (ACM) treated fibroblasts[2]
• as a component of large unilamellar vesicles for annexin A2 aggregation studies[3]

Azioni biochim/fisiol

1,2-Diacyl-sn-glycero-3-phospho-L-serine or phosphatidylserine (PS) is a structurally diverse acidic phospholipid having fatty acid ester at the glycerol sn positions. Bovine brain cortex based PS is a potent brain nutrient. It favors neurotransmission and may improve memory in dementia.[4] PS is also the major membrane phospholipid associated with the nuclear membrane, myelin, endoplasmic reticulum, Golgi and mitochondria.[5] The synthesis of PS is catalyzed by phosphatidylserine synthase 1 from L-serine and CDP-diacylglycerol in the mitochondria-associated membrane (MAM) domains of the endoplasmic reticulum.[6] PS is externalized during phagocytosis and is dysregulated in tumors making it a potential marker for therapeutic targeting.[7]

A slowly metabolized structural phospholipid found mainly in gray matter.

Caratteristiche e vantaggi

This compound is featured on the Phospholipase D and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Avvertenza

Solutions exposed to room temperature will decompose about 0.5% per day.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)