G8415

Acido L-glutammico

98.5-100.5%, suitable for cell culture, non-animal source, meets EP testing specifications

• Sinonimo/i: Acido (S)-2-amminopentanodioico, Glu
• Formula condensata: HO₂CCH₂CH₂CH(NH₂)CO₂H
• Numero CAS: 56-86-0
• Peso molecolare: 147.13
• Beilstein: 1723801
• Numero CE: 200-293-7
• Numero MDL: MFCD00002634
• Codice UNSPSC: 12352209
• eCl@ss: 32160406
• ID PubChem: 24895340
• NACRES: NA.26

Proprietà

• Nome del prodotto: Acido L-glutammico, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%
• Origine biologica: non-animal source
• Livello qualitativo: 300
• agenzia: meets EP testing specifications
• Saggio: 98.5-100.5%
• Stato: powder
• tecniche: cell culture | mammalian: suitable
• Impurezze: endotoxin, tested
• Colore: white
• Punto di fusione: 205 °C (dec.) (lit.)
• Solubilità: 1 M HCl: 100 mg/mL
• Densità: 1.54 g/cm³ at 20 °C
• Anioni in tracce: chloride (Cl^-): ≤200 ppm; sulfate (SO₄^2-): ≤200 ppm
• Cationi in tracce: As: ≤1 ppm, passes test; Fe: ≤10 ppm, passes test; NH₄⁺: ≤200 ppm, passes test
• applicazioni: pharmaceutical (small molecule)
• Stringa SMILE: N[C@@H](CCC(O)=O)C(O)=O
• InChI: 1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1; WHUUTDBJXJRKMK-VKHMYHEASA-N
• Informazioni sul gene: human ... CCR2(1231) , GRIA1(2890) , GRIA2(2891) , GRIA4(2893) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK5(2901) , GRIN2B(2904) , GRM2(2912) , SLC1A1(6505) , SLC1A2(6506) ; rat ... Gria1(50592) , Grik1(29559) , Grik2(54257) , Grik4(24406) , Grin2a(24409) , Grm1(24414) , Grm2(24415) , Grm3(24416) , Grm4(24417) , Grm5(24418) , Grm6(24419) , Grm7(81672) , Slc1a2(29482)

Descrizione

Applicazioni

L-Glutamic acid has been used as a supplement in for cell culture media to culture hippocampal neurons and hT-PA (human tissue plasminogen activation) producing cell line.[1][2][3]

Azioni biochim/fisiol

Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter and also serves as a precursor to other neurotransmitters such as γ-aminobutyric acid.[4] Glutamic acid also plays a key role in many metabolic pathways, that controls growth, reproduction, maintenance and immunity.[5] It is converted to α-ketoglutarate, a key component of the TCA (tricarboxylic acid) cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids.[5][6] In cells, glutamine is converted to glutamate by the enzyme glutaminase.[6] Glutamine serves as a source of energy for rapidly dividing cells comprising lymphocytes, enterocytes, macrophages and tumors. Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signaling. It is also known to be associated with the inhibition of apoptosis.[5]

Neurotrasmettitore aminoacidico eccitatorio, agonista di tutti i sottotipi di recettori del glutammato (metabotropico, cainato, NMDA e AMPA).

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)