L8912

L-Leucine

98.5-101.0%, suitable for cell culture, non-animal source, meets EP, JP, USP testing specifications

• Sinonimo/i: (S)-Leucine, (S)-2-Amino-4-methylpentanoic acid
• Formula condensata: (CH₃)₂CHCH₂CH(NH₂)CO₂H
• Numero CAS: 61-90-5
• Peso molecolare: 131.17
• Beilstein: 1721722
• Numero CE: 200-522-0
• Numero MDL: MFCD00002617
• Codice UNSPSC: 12352209
• eCl@ss: 32160406
• ID PubChem: 24896510
• NACRES: NA.26

Proprietà

• Nome del prodotto: L-Leucine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
• Origine biologica: non-animal source
• agenzia: USP/NF; meets EP testing specifications; meets JP testing specifications; meets USP testing specifications
• Saggio: 98.5-101.0%
• Stato: powder
• Attività ottica: [α]20/D 14.9 to 16.0°, c = 4 in 6 M HCl; [α]25/D 14.9 to 17.3 °, c = 4 in 6 M HCl
• Qualità: meets EP, JP, USP testing specifications
• tecniche: cell culture | mammalian: suitable
• Impurezze: endotoxin, tested
• Colore: white
• Punto di fusione: >300 °C (lit.)
• Solubilità: 1 M HCl: 50 mg/mL
• Cationi in tracce: As: ≤1 ppm; Fe: ≤10 ppm; NH₄⁺: <0.02%; heavy metals: ≤10 ppm
• applicazioni: peptide synthesis; pharmaceutical (small molecule)
• Gruppo funzionale: amine; carboxylic acid
• Temperatura di conservazione: room temp
• Stringa SMILE: CC(C)C[C@H](N)C(O)=O
• InChI: 1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1; ROHFNLRQFUQHCH-YFKPBYRVSA-N

Descrizione

Descrizione generale

Leucine is a non-glucogenic, and essential amino acid. It is a branched-chain amino acid that is a structural component of proteins.[1]

Applicazioni

L-Leucine has been used:

• as a hypertrophic agent to monitor its effects on myotubes.[2]
• as a component of PMG media for culturing yeast.[3]
• in myotube protein synthesis analysis in skeletal muscle cells.[4]
• to study its effects on hepatic lipid metabolism.[5]

Azioni biochim/fisiol

Leucine plays a role in intracellular signaling, gene transcription, and translation. It promotes the synthesis of protein by activating the mammalian target of the rapamycin (mTOR) signaling pathway in placental cells, skeletal muscles, and adipose tissue.[6] Leucine inhibits protein degradation and promotes mitochondrial biogenesis, glucose metabolism, and fatty acid oxidation to provide energy for protein synthesis.[1]

Altre note

For additional information on our range of Biochemicals, please complete this form.

The product is intended for laboratory use only, and it is not suitable for drug, household, or other purposes.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)