G1404

Glutathione reduced ethyl ester

≥90% (TLC)

• Sinonimo/i: γ-Glu-Cys-Gly-OEt, GSH-MEE
• Formula empirica (notazione di Hill): C₁₂H₂₁N₃O₆S
• Numero CAS: 92614-59-0
• Peso molecolare: 335.38
• Numero MDL: MFCD00156117
• Codice UNSPSC: 12161504
• ID PubChem: 329799840
• NACRES: NA.26

Proprietà

• Nome del prodotto: Glutathione reduced ethyl ester, ≥90% (TLC)
• Livello qualitativo: 200
• Saggio: ≥90% (TLC)
• Stato: powder
• Colore: white to off-white
• Temperatura di conservazione: −20°C
• Stringa SMILE: CCOC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O
• InChI: 1S/C12H21N3O6S/c1-2-21-10(17)5-14-11(18)8(6-22)15-9(16)4-3-7(13)12(19)20/h7-8,22H,2-6,13H2,1H3,(H,14,18)(H,15,16)(H,19,20)/t7-,8-/m0/s1; JKRODHBGNBKZLE-YUMQZZPRSA-N

Descrizione

Amino Acid Sequence

Glu-Cys-Gly-OEt

Applicazioni

Glutathione reduced ethyl ester has been used:

• to increase intracellular glutathione levels in mouse fibroblast L929 cells[1]
• as a medium supplement in Spodoptera frugiperda (Sf)9 cells[2]
• to evaluate its effect on lipid peroxidation after spinal cord injury[3]

Azioni biochim/fisiol

Glutathione reduced ethyl ester (GSH-MEE) is a membrane/lipid permeable derivative of GSH that may be used to partially supplement the GSH supply within cells subjected to cysteine and/or GSH depletion.[4] GSH-MEE is hydrolysed by intracellular esterases to release GSH, thereby increases the concentrations of intracellular GSH.[5][6] It prevents the toxic effects of acetaminophen in animal cells. It protects human lymphoid cells and skin fibroblasts against the damage caused due to radiation.[6]

Glutathione reduced ethyl ester inhibits melanin synthesis by inhibiting tyrosinase activity in Melan-A cells. Its antimelanogenic functionality has potential in treating hyperpigmentation skin disorders.[7] GEE supplementation during islets isolation form pancreas reduces reactive oxygen species production and apoptosis.[8]

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)