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F6300

Sigma-Aldrich

Flumazenil

>99% (HPLC), solid, benzodiazepine receptor antagonist

Sinonimo/i:

Ro 15-1788, Ro15-1788

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About This Item

Formula empirica (notazione di Hill):
C15H14FN3O3
Numero CAS:
78755-81-4
Peso molecolare:
303.29
Numero MDL:
MFCD00242764
Codice UNSPSC:
12352200
ID PubChem:
24278437
NACRES:
NA.77

Nome del prodotto

Flumazenil, >99% (HPLC), solid

Livello qualitativo

100

Saggio

>99% (HPLC)

Stato

solid

Colore

white

Ideatore

Roche

Temperatura di conservazione

2-8°C

Stringa SMILE

CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(F)ccc-23

InChI

1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
OFBIFZUFASYYRE-UHFFFAOYSA-N

Informazioni sul gene

human ... BZRAP1(9256) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)
rat ... Gabra2(29706) , Gabrg1(140674)

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Descrizione generale

Flumazenil reverses sedative and hypnotic effects of benzodiazepines. It is used to increase acquisition, enhance retention and treat amnesia in mice.

Azioni biochim/fisiol

Highly specific benzodiazepine receptor antagonist.

Caratteristiche e vantaggi

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
MKCX0221
MKCT8059
MKCN7054
MKCG7793
MKCB6548

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Sigma-Aldrich

C6240

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Omeprazolo solid

Sigma-Aldrich

O104

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Phaclofen solid

Sigma-Aldrich

P118

Phaclofen

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Supelco

PHR1623

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(+)-Bicuculline ≥97.0% (TLC)

Sigma-Aldrich

14340

(+)-Bicuculline

PK 11195

Sigma-Aldrich

C0424

PK 11195

Luzindole ≥90%

Sigma-Aldrich

L2407

Luzindole

Donna L Seger
Journal of toxicology. Clinical toxicology, 42(2), 209-216 (2004-06-25)
Flumazenil is frequently administered to the poisoned patient. Seizures may be precipitated and resedation may occur in patients who awakened following flumazenil administration. Seizures may increase morbidity and mortality of the overdose. Benefit:Risk ratio of administering flumazenil should be determined
A A Weinbroum et al.
Drug safety, 17(3), 181-196 (1997-11-05)
The worldwide expansion in the use of benzodiazepines has led to their frequent, and often inappropriate, use and to increase in their involvement in self-induced poisoning and iatrogenic overdosing. Flumazenil is a specific and competitive antagonist at the central benzodiazepine
A A Weinbroum et al.
European journal of anaesthesiology, 18(12), 789-797 (2001-12-12)
Midazolam may occasionally precipitate hostility and violence instead of tranquility. We characterized these episodes, their rate of occurrence, the potential paradoxical responders and possible predisposing circumstances among patients undergoing lower body surgery under spinal or epidural anaesthesia and midazolam sedation.
N W Duncan et al.
Neuroscience, 235, 226-231 (2013-02-06)
Voxel based morphometry (VBM) is a widely used technique for studying the structure of the brain. Direct comparisons between the results obtained using VBM and the underlying histology are limited, however. To circumvent the problems inherent in comparing VBM data
Effect of flumazenil on memory retrieval determined by trial-to-criteria inhibitory avoidance method in mice
Raut SB, et al.
Journal of Pharmacology & Pharmacotherapeutics, 7(1), 24-24 (2016)
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