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F1678

Sigma-Aldrich

R-(−)-Fluoxetine hydrochloride

>98% (HPLC), solid

Sinonimo/i:

(R)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C17H18NOF3 · HCl
Numero CAS:
114247-09-5
Peso molecolare:
345.79
Numero MDL:
MFCD04040065
Codice UNSPSC:
12352200
ID PubChem:
24278433
NACRES:
NA.77

Livello qualitativo

100

Saggio

>98% (HPLC)

Forma fisica

solid

Condizioni di stoccaggio

desiccated

Colore

white

Solubilità

H2O: soluble >10 mg/mL

Ideatore

Eli Lilly

Stringa SMILE

Cl[H].CNCC[C@@H](Oc1ccc(cc1)C(F)(F)F)c2ccccc2

InChI

1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H/t16-;/m1./s1
GIYXAJPCNFJEHY-PKLMIRHRSA-N

Informazioni sul gene

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363)

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Applicazioni

R-(−)-Fluoxetine hydrochloride has been used as a serotonin reuptake inhibitor:
  • to study its effects on the embryoid body (EB) morphogenesis
  • in combination with muscimol hydrobromide (MUS) as well as individually to study its neurotoxic effects on neuronal cells grown on multielectrode array (MEA) chips
  • to study its effects as an endocrine disruption inducer in Pimephales promelas

Azioni biochim/fisiol

Fluoxetine exhibits anti-depressant activity by increasing the serotonin levels in the neuron synaptic space. It also exhibits therapeutic effects against depression and other mood disorders.
Selective serotonin reuptake inhibitor.

Caratteristiche e vantaggi

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Applicazioni

N° Catalogo
Descrizione
Determinazione del prezzo

Pittogrammi

CorrosionExclamation mark
GHS05,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H302,H315,H318

Classi di pericolo

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Bibiana Scelfo et al.
Toxicology, 299(2-3), 172-183 (2012-06-06)
Cortical neurons grown on multielectrode array (MEA) chips have been shown to be a valuable alternative method to study electrophysiological properties of the central nervous system neurons and to perform functional toxicological screening. Here we studied the effects of binary
Erica L L Warkus et al.
Toxicological sciences : an official journal of the Society of Toxicology, 165(2), 372-388 (2018-06-13)
Fluoxetine is one of the most commonly prescribed antidepressants in the selective serotonin reuptake inhibitor (SSRI) class. Epidemiologic studies have suggested a link between maternal fluoxetine use during pregnancy and an increased incidence of birth defects. However, the mechanisms by
Maria Gonzalez-Rey et al.
Environmental pollution (Barking, Essex : 1987), 173, 200-209 (2012-12-04)
Fluoxetine (FLX) the active pharmaceutical ingredient (API) in Prozac(®) is a widely prescribed psychoactive drug which ubiquitous occurrence in the aquatic environment is associated to a poor removal rate in waste-water treatment plant (WWTP) systems. This API acts as a
Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the

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