The solubility of dexamethasone is <0.01 mg/mL in water and 24 mg/mL in H5784 (a 45% w/v solution of 2-hydroxypropyl-β-cyclodextrin).
D8893
Desametasone
powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC)
Sinonimo/i:
(11β,16α)-9-fluoro-11,17,21-triidrossi-16-metilpregna-1,4-diene-3,20-dione, 9α-fluoro-16α-metil-11β,17α,21-triidrossi-1,4-pregnadiene-3,20-dione, 9α-fluoro-16α-metilprednisolone, Prednisolone F
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About This Item
Formula empirica (notazione di Hill):
C22H29FO5
Numero CAS:
Peso molecolare:
392.46
Beilstein:
2066651
Numero CE:
Numero MDL:
Codice UNSPSC:
12352209
ID PubChem:
NACRES:
NA.77
Origine biologica:
synthetic (organic)
Stato:
powder
Saggio:
≥80% (HPLC)
Prodotti consigliati
Origine biologica
synthetic (organic)
Livello qualitativo
Sterilità
γ-irradiated
Nome Commerciale
BioXtra
Saggio
≥80% (HPLC)
Stato
powder
Potenza
4-500 ng/mL
tecniche
cell culture | mammalian: suitable
Punto di fusione
262-264 °C (lit.)
Solubilità
ethanol: 1 mL/vial, clear
Condizioni di spedizione
ambient
Temperatura di conservazione
2-8°C
Stringa SMILE
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
InChI
1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
UREBDLICKHMUKA-CXSFZGCWSA-N
Informazioni sul gene
human ... ABCB1(5243) , CYP3A4(1576) , IL4(3565) , IL5(3567) , NR3C1(2908)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) , Ptgs2(19225) , Tnf(21926)
rat ... Ar(24208) , Nr3c1(24413) , Tnf(24835)
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Applicazioni
Azioni biochim/fisiol
Agente antinfiammatorio glucocorticoide
Agente antinfiammatorio glucocorticoide. Regola la sopravvivenza, la crescita e la differenziazione delle cellule T. Inibisce l′induzione dell′ossido nitrico sintasi.
Dexamethasone has immunosuppressant and antiemetic properties. It is used to treat postoperative nausea and vomiting (PONV) and chemotherapy-induced nausea and vomiting (CINV).[4] Dexamethasone plays an important role in cardiac transplant, sepsis, cancer and other pathologic disorders. It elevates the level of heat shock proteins.[5] It is an anti-inflammatory glucocorticoid with a range of effects on cell survival, cell signaling and gene expression.
Stato fisico
powder 2-8 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw
Ricostituzione
To prepare 20 μg/ml stock solution: add 1 ml absolute ethanol; gently swirl to dissolve; add 49 ml sterile medium while mixing.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Repr. 1B
Codice della classe di stoccaggio
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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What is the best way to dissolve Product D8893, Dexamethasone?
1 risposta-
Utile?
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What is the solubility of Product D8893, Dexamethasone, in ethanol?
1 risposta-
The product is soluble in 95% ethanol (1mg/mL), yielding a clear, colorless solution. A 20 μg/mL stock solution can be formed by adding 49 mL of media to 1 mL of a 1 mg/mL ethanol stock.
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What is the Department of Transportation shipping information for this product?
1 risposta-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How do the dexamethasone products D8893 and the D4902 compare?
1 risposta-
They are the same except for the sterility. D8893 has been g-irradiated, so it is sterile. The D4902 is not necessarily sterile. Both are cell culture tested by Sigma.
Utile?
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What solution stability information do you have available for Product D8893, Dexamethasone?
1 risposta-
We would recommend that you store stock solutions in working aliquots frozen at -20°C. It is best to avoid repeated freeze/thaw cycles.
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What is the solubility of Product D8893, Dexamethasone, in DMSO?
1 risposta-
The solubility of dexamethasone in DMSO is 606 mg/mL at 25°C.
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