D1756

Desametasone

≥98% (HPLC), powder, NOS induction inhibitor

• Sinonimo/i: (11β,16α)-9-fluoro-11,17,21-triidrossi-16-metilpregna-1,4-diene-3,20-dione, 9α-fluoro-16α-metil-11β,17α,21-triidrossi-1,4-pregnadiene-3,20-dione, 9α-fluoro-16α-metilprednisolone, Prednisolone F
• Formula empirica (notazione di Hill): C₂₂H₂₉FO₅
• Numero CAS: 50-02-2
• Peso molecolare: 392.46
• Beilstein: 2066651
• Numero CE: 200-003-9
• Numero MDL: MFCD00064136
• Codice UNSPSC: 51422306
• ID PubChem: 24893536
• NACRES: NA.77

Proprietà

• Nome del prodotto: Desametasone, ≥98% (HPLC), powder
• Livello qualitativo: 200
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: off-white
• Punto di fusione: 262-264 °C (lit.)
• Solubilità: methanol: 25 mg/mL
• Ideatore: Merck & Co., Inc., Kenilworth, NJ, U.S.
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
• InChI: 1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1; UREBDLICKHMUKA-CXSFZGCWSA-N
• Informazioni sul gene: human ... ABCB1(5243) , CYP3A4(1576) , IL4(3565) , IL5(3567) , NR3C1(2908) ; mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) , Ptgs2(19225) , Tnf(21926) ; rat ... Ar(24208) , Nr3c1(24413) , Tnf(24835)

Descrizione

Descrizione generale

Dexamethasone is a potent glucocorticoid with minimal to no mineralocorticoid activity. Dexamethasone exhibits pleiotropic effects on multiple signaling pathways,[1] some of its functions include, inhibition of neutrophil migration and reduction of lymphocyte colony proliferation. Research findings show, dexamethasone might prevent high-altitude pulmonary edema by decreasing pulmonary artery pressure.

Applicazioni

Dexamethasone has been used:

• in culture media to induce differentiation of adipose-derived stem cells into osteogenic tissue[2]
• as a component of adipocyte differentiation medium[3]
• for in vitro stimulation of primary normal human bronchial epithelial cells (NHBE) and airway smooth muscle (ASM)[4]

Azioni biochim/fisiol

Agente antinfiammatorio glucocorticoide

Agente antinfiammatorio glucocorticoide. Regola la sopravvivenza, la crescita e la differenziazione delle cellule T. Inibisce l′induzione dell′ossido nitrico sintasi.

Dexamethasone is known to be effective against relapsed multiple myeloma.[5] It is found to decrease inflammation associated with cerebrospinal fluid and central nervous system (CNS) complications, such as hearing loss.[6]

Caratteristiche e vantaggi

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Nota sulla preparazione

Dexamethasone is soluble in DMSO (25 mg/ml), chloroform or ethanol.

Ricostituzione

Dilute 1 mg/ml stock solution 1:50 with sterile media and store frozen in working aliquots to avoid repeated freeze-thaw.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H360FD
• Consigli di prudenza: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classi di pericolo: Repr. 1B
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves