The solubility of this produst is tested in water at 50 mg/mL The solubility in saline has not been tested, however rates are expected to be similar. The solution stability has not been determined. Other sources state that solutions are stable for up to 1 month when stored in aliquots at -20°C.
D1159
Dexamethasone 21-phosphate disodium salt
≥98%
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100 MG
114,00 €
500 MG
344,00 €
1 G
573,00 €
5 G
2.300,00 €
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Cambia visualizzazione
100 MG
114,00 €
500 MG
344,00 €
1 G
573,00 €
5 G
2.300,00 €
About This Item
Formula empirica (notazione di Hill):
C22H28FNa2O8P
Numero CAS:
Peso molecolare:
516.40
Beilstein:
6473066
Numero CE:
Numero MDL:
Codice UNSPSC:
51422340
ID PubChem:
NACRES:
NA.25
Prodotti consigliati
Saggio
≥98%
Stato
powder
Impurezze
≤1% ethanol
Colore
white to off-white
Temperatura di conservazione
2-8°C
Stringa SMILE
[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O
InChI
1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1
PLCQGRYPOISRTQ-FCJDYXGNSA-L
Informazioni sul gene
human ... NR3C1(2908)
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Categorie correlate
Applicazioni
Dexamethasone 21-phosphate disodium salt has been used:
- as a positive control to study its effects on ocular shedding of herpes simplex virus type 1 (HSV-1) in the induced reactivation (IR) and spontaneous shedding (SS) rabbit models[1]
- as a receptor analog to study its effects on glucocorticoid receptor activation in suprachiasmatic nuclei (SCN)-lesioned mice[2]
- to study its protective effects against cisplatin-induced ototoxicity in the inner ear of guinea pigs[3]
Azioni biochim/fisiol
Dexamethasone 21-phosphate (Dex 21-P) is a pro-drug[4] that can undergo dephosphorylation to form dexamethasone with the help of intra-erythrocyte enzymes.[5] It exhibits therapeutic effects against cystic fibrosis[4] and postoperative cataract.[6] Dex 21-P disodium salt is a synthetic adrenal corticosteroid and possesses anti-inflammatory activity.[6]
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 4 Oral - Repr. 2
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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A novel extrusion printing system was used to create drug delivery structures wherein dexamethasone-21-phosphate disodium salt (Dex21P) was encapsulated within a biodegradable polymer (PLGA) and water soluble poly(vinyl alcohol) (PVA) configurations. The ability to control the drug release profile through
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We planned to dissolve it into saline and use to to inject as prenatal stressor to Sprague-Dawley rats via IP way. What is the solubility? I want to dissolve 100µg and 200µg into 10ml of saline. After dissolving what is the shelf life of that solution?
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