C4438

2-Chloro-2′-deoxyadenosine

antileukemic

• Sinonimo/i: CdA, Cladribine
• Formula empirica (notazione di Hill): C₁₀H₁₂ClN₅O₃
• Numero CAS: 4291-63-8
• Peso molecolare: 285.69
• Numero MDL: MFCD00153939
• Codice UNSPSC: 41106305
• ID PubChem: 24892693
• NACRES: NA.51

Proprietà

• Livello qualitativo: 200
• Saggio: ≥98% (HPLC)
• Forma fisica: powder or crystals
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Nc1nc(Cl)nc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO)O3
• InChI: 1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1; PTOAARAWEBMLNO-KVQBGUIXSA-N
• Informazioni sul gene: human ... NP(4860) ; rat ... Adora1(29290) , Adora2a(25369) , Adora3(25370)

Descrizione

Applicazioni

2-Chloro-2′-deoxyadenosine (2-CdA) is a chlorinated purine nucleoside with activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL) and multiple myeloma (MM). 2-CdA resists ADA degradation and is phosphorylated to CdATP in lymphocytes. CdATP incorporation into DNA induces strand breaks and the activation of apoptosis. 2-CdA may also be used in studies involving the inhibition of DNA polymerase(s).
Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK).

Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK). Clinically used for treatment of hairy cell leukemia, chronic lymphocytic leukemia and other indolent leukemias.

Azioni biochim/fisiol

Deoxyadenosine analog resistant to adenosine deaminase; antileukemic with immunosuppressive activity

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H301,H341,H361fd,H372
• Consigli di prudenza: P202 - P260 - P264 - P280 - P301 + P310 - P405
• Classi di pericolo: Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges