Passa al contenuto
Merck
Tutte le immagini(1)

Documenti

30450

Sigma-Aldrich

Daunorubicin hydrochloride

≥90% (HPLC)

Sinonimo/i:

Daunomycin hydrochloride

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C27H29NO10 · HCl
Numero CAS:
23541-50-6
Peso molecolare:
563.98
Beilstein:
4229221
Numero CE:
245-723-4
Numero MDL:
MFCD04974507
Codice UNSPSC:
51102829
ID PubChem:
57648441
NACRES:
NA.85

Origine biologica

synthetic

Saggio

≥90% (HPLC)

Forma fisica

powder

Colore

red to deep red

Spettro attività antibiotica

neoplastics

Modalità d’azione

DNA synthesis | interferes

Temperatura di conservazione

2-8°C

Stringa SMILE

Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O

InChI

1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
GUGHGUXZJWAIAS-QQYBVWGSSA-N

Informazioni sul gene

human ... TOP2A(7153)

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Descrizione generale

Chemical structure: aminoglycoside

Applicazioni

Daunorubicin hydrochloride is used in photostability, antileukemic, and drug metabolism studies.

Azioni biochim/fisiol

On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. Daunomycin effectively binds to every 3 base pairs which causes unwinding.
Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent.

Confezionamento

5 mg, 25 mg

Altre note

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Store under inert gas.

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H301,H341,H351,H360FD

Classi di pericolo

Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 6

1 of 6

Mitoxantrone dihydrochloride ≥97% (HPLC)

Sigma-Aldrich

M6545

Mitoxantrone dihydrochloride

Doxorubicina Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1789

Doxorubicina

Cytosine β-D-arabinofuranoside crystalline, ≥90% (HPLC)

Sigma-Aldrich

C1768

Cytosine β-D-arabinofuranoside

Cytarabine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1787

Cytarabine

Doxorubicina European Pharmacopoeia (EP) Reference Standard

D2975000

Doxorubicina

Cytarabine British Pharmacopoeia (BP) Reference Standard

BP383

Cytarabine

Photoprotection of Daunorubicin Hydrochloride with Sodium Sulfite.
Mohammad S. Islam* and Ahmed F. Asker
Journal of Pharmaceutical Sciences, 49, 122-126 (1995)
I-Shan Hsieh et al.
Molecular pharmacology, 83(5), 968-977 (2013-02-26)
Multidrug resistance is a major cause of chemotherapy failure. Recent studies indicate that drug resistance can be rapidly induced by some soluble factors, such as cytokines, chemokines, growth factors, and cell adhesion factors in the tumor microenvironment. Osteopontin (OPN), an
Sarah Bertoli et al.
Blood, 121(14), 2618-2626 (2013-02-01)
In acute myeloid leukemia (AML), new strategies assess the potential benefit of genetically targeted therapy at diagnosis. This implies waiting for laboratory tests and therefore a delay in initiation of chemotherapy. We studied the impact of time from diagnosis to
Oliver Teuffel et al.
British journal of haematology, 161(2), 192-203 (2013-02-13)
This systematic review and meta-analysis compared the efficacy of different anthracyclines and anthracycline dosing schedules for induction therapy in acute myeloid leukaemia in children and adults younger than 60 years of age. Twenty-nine randomized controlled trials were eligible for inclusion in
Kevin W H Yee et al.
Blood, 104(13), 4202-4209 (2004-08-12)
Fetal liver tyrosine kinase 3 internal tandem duplication (FLT3 ITD) mutations are the most common molecular abnormality associated with adult acute myeloid leukemia (AML). To exploit this molecular target, a number of potent and specific FLT3 kinase inhibitors have been
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.