A8404

Amitriptyline hydrochloride

≥98% (TLC), powder

• Formula empirica (notazione di Hill): C₂₀H₂₃N · HCl
• Numero CAS: 549-18-8
• Peso molecolare: 313.86
• Numero CE: 208-964-6
• Numero MDL: MFCD00012537
• Codice UNSPSC: 12352200
• ID PubChem: 24278073
• NACRES: NA.77

Proprietà

• Livello qualitativo: 200
• Saggio: ≥98% (TLC)
• Stato: powder
• Colore: white to off-white
• Solubilità: H₂O: soluble; ethanol: soluble
• Ideatore: Bristol-Myers Squibb
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
• InChI: 1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H; KFYRPLNVJVHZGT-UHFFFAOYSA-N
• Informazioni sul gene: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133) , SLC6A2(6530) , SLC6A4(6532)

Descrizione

Applicazioni

Amitriptyline hydrochloride has been used:

• as an antidepressant to study its effects on social behavior and memory in transgenic for acid sphingomyelinase (t-ASM) mice[1]
• as a tricyclic antidepressant to analyze its effects on glucocorticoid receptor function in whole human blood[2]
• as an anti-depressant to study its effects on scratching and locomotion behavior in chloroquine-induced mouse[3]

Azioni biochim/fisiol

Amitriptyline hydrochloride shows therapeutic effects against anxiety, maniac depression, and involutional melancholia.[4] It possesses antihistaminic, anticholinergic, and antiserotonimic properties.[5] Amitriptyline hydrochloride acts as an amphiphilic agent and exhibits neuroleptic activity.[4]

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with K_is of 100 nM and 14.7 nM, respectively; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Caratteristiche e vantaggi

Shelf-life of the powder is at least three years.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H301,H319,H361d,H410
• Consigli di prudenza: P201 - P273 - P301 + P310 + P330 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges