1029002

Amitriptyline hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Formula empirica (notazione di Hill): C₂₀H₂₃N · HCl
• Numero CAS: 549-18-8
• Peso molecolare: 313.86
• NACRES: NA.24
• PubChem Substance ID: 329749005
• UNSPSC Code: 41116107
• MDL number: MFCD00012537

Proprietà

• grade: pharmaceutical primary standard
• agency: USP
• API family: amitriptyline
• manufacturer/tradename: USP
• application(s): pharmaceutical; pharmaceutical (small molecule)
• format: neat
• SMILES string: Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
• InChI: 1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
• InChI key: KFYRPLNVJVHZGT-UHFFFAOYSA-N
• Gene Information: human ... SLC6A2(6530), SLC6A4(6532)

Descrizione

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Amitriptyline hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Amitriptyline Hydrochloride Tablets
• Chlordiazepoxide and Amitriptyline Hydrochloride Tablets
• Cyclobenzaprine Hydrochloride Extended-Release Capsules
• Perphenazine and Amitriptyline Hydrochloride Tablets

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with K_is of 100 nM and 14.7 nM, respectively; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Tricyclic antidepressant; norepinephrine and serotonin transporter inhibitor; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08,GHS09
• Parola di avvertenza: Danger
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
• Classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable
• Codici di pericolo: H301,H319,H361fd,H410
• Avvertenze di sicurezza: P202 - P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338