01810

Cycloheximide

≥90% (HPLC)

• Sinonimo/i: 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
• Formula empirica (notazione di Hill): C₁₅H₂₃NO₄
• Numero CAS: 66-81-9
• Peso molecolare: 281.35
• Beilstein: 88868
• Numero CE: 200-636-0
• Numero MDL: MFCD00082346
• Codice UNSPSC: 51102829
• ID PubChem: 329747360
• NACRES: NA.85

Proprietà

• Origine biologica: microbial
• Livello qualitativo: 200
• Saggio: ≥90% (HPLC)
• Stato: powder or crystals
• Colore: white to light beige
• Spettro attività antibiotica: fungi; yeast
• Modalità d’azione: protein synthesis | interferes
• Stringa SMILE: N1C(=O)CC(CC1=O)C[C@@H](O)[C@@H]2C[C@H](C[C@@H](C2=O)C)C
• InChI: 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1; YPHMISFOHDHNIV-FSZOTQKASA-N
• Informazioni sul gene: human ... FKBP1A(2280) , PIN1(5300)

Descrizione

Applicazioni

Cyclohexamide (CHX) is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis[1][2] for detection of short-lived proteins, super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques,[3] activate cumulus-free equine oocytes,[4] and to have neuroprotective properties.[5]

Azioni biochim/fisiol

Cyclohexamide inhibits protein biosynthesis in eukaryotic cells by binding with the 80S ribosome.[6]

Cycloheximide (CHX) is an antibiotic produced by Strptomyces sp.. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Confezionamento

1G, 5G

Altre note

Conditions for safe storage, including any incompatibilities. Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H300,H341,H360D,H411
• Consigli di prudenza: P202 - P264 - P273 - P280 - P301 + P310 - P391
• Classi di pericolo: Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges