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676380

Sigma-Aldrich

Valproic Acid sodium salt

≥98% (HPLC), solid, HDAC1 inhibitor, Calbiochem®

Sinonimo/i:

Valproic Acid, Sodium Salt, 2-Propylpentanoic Acid, Na

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5 G
101,00 €

101,00 €

Spedizione prevista il17 aprile 2025Dettagli

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5 G
101,00 €

About This Item

Formula empirica (notazione di Hill):
C8H15NaO2
Numero CAS:
1069-66-5
Peso molecolare:
166.19
Numero MDL:
MFCD00078604
Codice UNSPSC:
12352106
NACRES:
NA.77

101,00 €

Spedizione prevista il17 aprile 2025Dettagli

Nome del prodotto

Valproic Acid, Sodium Salt, A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC₅₀ = 400 µM for HDAC1).

Livello qualitativo

100

Descrizione

Merck USA index - 14, 9913

Saggio

≥98% (HPLC)

Stato

solid

Potenza

400 μM IC50

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

OK to freeze
desiccated (hygroscopic)

Colore

white

Solubilità

water: 50 mg/mL

Condizioni di spedizione

ambient

Temperatura di conservazione

2-8°C

Stringa SMILE

[Na+].[O-]C(=O)C(CCC)CCC

InChI

1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
AEQFSUDEHCCHBT-UHFFFAOYSA-M

Descrizione generale

A cell-permeable, short-chained fatty acid that inhibits histone deacetylase activity (IC50 = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (350 µM-1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates the ERK pathway, and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.

Azioni biochim/fisiol

Cell permeable: yes
Primary Target
HDAC1
Product does not compete with ATP.
Reversible: no

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Altre note

Gottlicher, M., et al. 2001. EMBO J.20, 6969.
Knupfer, M.M., et al. 2001. Anticancer Res.21, 347.
Phiel, C.J., et al. 2001. J. Biol. Chem.276, 36734.
Vaden, D.L., et al. 2001. J. Biol. Chem.276, 15466.
Yuan, P.X., et al. 2001. J. Biol. Chem.276, 31674.
Chen, G., et al. 1999. J. Neurochem.72, 1327.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H361d

Classi di pericolo

Acute Tox. 4 Oral - Repr. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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