706531

N-Boc-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester

95%

• Sinonimo/i: (1-tert-Butoxycarbonyl-1,2,3,6-tetrahydropyridin-4-yl)boronic acid pinacol ester, (N-tert-Butoxycarbonyl-1,2,3,6-tetrahydropyridin-4-yl)boronic acid pinacol ester, (N-tert-Butoxycarbonyl-1,2,5,6-tetrahydropyridin-4-yl)boronic acid pinacol ester, (N-tert-Butoxycarbonyl)-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester
• Formula empirica (notazione di Hill): C₁₆H₂₈BNO₄
• Numero CAS: 286961-14-6
• Peso molecolare: 309.21
• Numero MDL: MFCD03840345
• Codice UNSPSC: 12352103
• ID PubChem: 329762650
• NACRES: NA.22

Proprietà

• Livello qualitativo: 100
• Saggio: 95%
• Stato: powder
• Punto di fusione: 100-114 °C
• Stringa SMILE: CC(C)(C)OC(=O)N1CCC(=CC1)B2OC(C)(C)C(C)(C)O2
• InChI: 1S/C16H28BNO4/c1-14(2,3)20-13(19)18-10-8-12(9-11-18)17-21-15(4,5)16(6,7)22-17/h8H,9-11H2,1-7H3; VVDCRJGWILREQH-UHFFFAOYSA-N

Descrizione

Descrizione generale

Boc-THP-Bpin is frequently used in metal catalyzed cross-coupling reactions, such as Suzuki-Miyaura and Negishi couplings.[1][2]

Applicazioni

Reagent used for

• Suzuki-Miyaura cross-coupling using palladium phosphine catalyst[1]
• Palladium-catalyzed ligand-controlled regioselective Suzuki coupling[2]
• Palladium-catalyzed Suzuki-Miyaura coupling[3]
• Suzuki coupling followed by iodolactonization reaction[4]
• Wrenchnolol derivative optimized for gene activation in cells[5]

Reagent used in Preparation of several enzymatic inhibitors and receptor ligands

• Orally active anaplastic lymphoma kinase inhibitors[6]
• Oxazolecarboxamides as diacylglycerol acyltransferase-1 inhibitors for treatment of obesity and diabetes[7]
• 4-arylpiperidinyl amides and N-arylpiperidin-3-yl-cyclopropanecarboxamides as novel melatonin receptor ligands[8]
• Quinazoline analogs as glucocerebrosidase inhibitors with chaperone activity for treatment of Gaucher disease, a lysosomal storage disorder[9]
• Arylpiperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists[10]

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)