T7947

(R)-Tomoxetine hydrochloride

solid

• Szinonimák: (R)-N-Methyl-γ-(2-methyl­phenoxy)benzenepropanamine hydrochloride, Atomoxetine hydrochloride
• Tapasztalati képlet (Hill-képlet): C₁₇H₂₁NO · HCl
• CAS-szám: 82248-59-7
• Molekulatömeg: 291.82
• MDL-szám: MFCD06410992
• UNSPSC kód: 12352200
• PubChem Substance ID: 24278760
• NACRES: NA.77

Tulajdonságok

• Forma: solid
• Minőségi szint: 100
• kezdeményező: Eli Lilly
• tárolási hőmérséklet: 2-8°C
• SMILES string: CNCC[C@@H](OC1=CC=CC=C1C)C2=CC=CC=C2.[H]Cl
• InChI: 1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
• Nemzetközi kémiai azonosító kulcs: LUCXVPAZUDVVBT-UNTBIKODSA-N
• Géninformáció: human ... SLC6A2(6530)

Leírás

Alkalmazás

(R)-Tomoxetine hydrochloride has been used as a noradrenaline reuptake inhibitor:

• to study the role of L-threo-3,4-dihydroxyphenylserine (L-DOPS) in the pathogenesis of Alzheimer′s disease in mice
• to study its effects on set shifting in rats
• to study its effects on rat brain as a result of its long-term use

Biokémiai/fiziológiai hatások

(R)-Tomoxetine hydrochloride is an efficient inhibitor of presynaptic norepinephrine transporters. It also positively regulates the release of acetylcholine in the prefrontal cortex (PFC). (R)-Tomoxetine hydrochloride binds to the serotonin (5-HT) transporter. It is involved in blocking the cortical N-methyl-D-aspartate (NMDA) receptors.. (R)-Tomoxetine hydrochloride exhibits therapeutic effects against attention-deficit/hyperactivity disorder (ADHD) and comorbid oppositional defiant disorder (ODD).

Norepinephrine uptake blocker.

Tulajdonságok és előnyök

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)