F132

Fluoxetine hydrochloride

≥98% (TLC), solid, selective serotonin reuptake inhibitor 

• Szinonimák: Fluoxetine HCl, (±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride, LY-110,140 hydrochloride, Prozac^®
• Tapasztalati képlet (Hill-képlet): C₁₇H₁₈F₃NO · HCl
• CAS-szám: 56296-78-7
• Molekulatömeg: 345.79
• EC-szám: 260-101-2
• MDL-szám: MFCD00214288
• UNSPSC kód: 12352200
• PubChem Substance ID: 24278096
• NACRES: NA.77

Tulajdonságok

• Terméknév: Fluoxetine hydrochloride, solid
• Forma: solid
• Minőségi szint: 200
• szín: white
• oldhatóság: H₂O: 4 mg/mL; DMSO: >5 mg/mL
• kezdeményező: Eli Lilly
• SMILES string: CNCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.[H]Cl
• InChI: 1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H
• Nemzetközi kémiai azonosító kulcs: GIYXAJPCNFJEHY-UHFFFAOYSA-N
• Géninformáció: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

Leírás

Általános leírás

Fluoxetine hydrochloride is a psychotropic agent and one of the initial members of the anti-depressant class of drugs known as selective serotonin-reuptake inhibitors (SSRIs). It is the active ingredient of Prozac^®.

Alkalmazás

Fluoxetine hydrochloride has been used to study its effect on the binding ability of the radiopharmaceutical 123I-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (^[123I]ADAM) to SERT (serotonin transporters) in mice. It has also been used for the chronic treatment of light deprived animals.It has also been used as a serotonin reuptake inhibitor to study its effects on acute stress in fish.

Biokémiai/fiziológiai hatások

Fluoxetine hydrochloride works at presynaptic terminals where it prevents the reuptake of serotonin, resulting in the accumulation of serotonin in extracellular fluid at synapses.

Selective serotonin reuptake inhibitor; antidepressant.

Tulajdonságok és előnyök

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Biogenic Amine Transporters and Chloride Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Jogi információk

Sold under license from Eli Lilly and Company.

Prozac is a registered trademark of Eli Lilly and Co.

Biztonsági adatok

• Piktogramok: GHS08,GHS05,GHS07,GHS09
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H302,H318,H336,H373,H410
• Óvintézkedésre vonatkozó mondatok: P260 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P314
• Veszélyességi osztályok: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - STOT RE 2 - STOT SE 3
• Célzott szervek: Central nervous system
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: dust mask type N95 (US), Eyeshields, Faceshields, Gloves