SRP4596
IFN-alpha 1 human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Szinonimák:
IFN-α 1, IFNA1, Interferon-α
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Javasolt termékek
biológiai forrás
human
rekombináns
expressed in E. coli
Teszt
≥95% (HPLC)
≥95% (SDS-PAGE)
Forma
lyophilized
hatékonyság
1x10^8 units/mg
molekulatömeg
~19.3 kDa
kiszerelés
pkg of 100 μg
tárolási körülmény
avoid repeated freeze/thaw cycles
szennyeződések
endotoxin, tested
NCBI elérési szám
UniProt elérési szám
kiszállítva
wet ice
tárolási hőmérséklet
−20°C
Géninformáció
human ... IFNA1(3439)
Általános leírás
IFN-α1 (interferon α 1) is a type 1 interferon. Human IFN-a1 is a 19.3kDa protein containing 166 amino acid residues. IFN-α1 belongs to the type I interferon (IFN) family and is present in leukocytes. The IFN-α1 gene is mapped to human chromosome 9p21.3.
Alkalmazás
IFN-alpha 1 human has been used:
- to treat Vero and breast cancer (MDA-MB-231) cells in interferon assay before viral infection
- as a ligand to vaccinia virus B18R protein in analytical size exclusion chromatography
- to treat chikungunya infected human embryonic kidney cell line (HEK293T) to test its effect on Signal transducer and activator of transcription 1 (STAT1) phosphorylation
- as recombinant interferon to treat lung fibroblast cell line (IMR90) to monitor histone chaperone (HIRA) response
Biokémiai/fiziológiai hatások
IFN-α1 (interferon α 1) is a lymphoid factor that possesses potent anti-viral activity. IFN-α1 interacts with IFNAR1 (interferon α receptor 1) and IFNAR2. The interaction activates JAK1 (janus-activated kinase 1) and tyrosine kinase 2. These events phosphorylate and activate STAT1 and STAT2 (signal transducer and activator of transcription proteins), leading to the upregulation of interferon-stimulated genes some of which encode antiviral proteins. IFN-alpha 1 (IFN-α1) mediates apoptosis in specific tissues. It may be useful in treating laryngeal carcinoma. The interaction of microRNA, miR-181b with IFN-α1, is regarded as a risk factor in systemic lupus erythematosus.
Fizikai forma
Lyophilized without any additives.
Feloldás
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1 mg/mL. This solution can then be diluted into other aqueous buffers.
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Analitikai tanúsítványok (COA)
Lot/Batch Number
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Az ügyfelek ezeket is megtekintették
K Oritani et al.
Cytokine & growth factor reviews, 12(4), 337-348 (2001-09-07)
The type I interferon (IFN) family includes IFN-alpha, IFN-beta, IFN-pi, and IFN-tau. These molecules are clustered according to sequence homologies, use of the same cell surface receptor, and similar functions. IFN-alpha and IFN-beta have a globular structure composed of five
Purification and characterization of multiple components of human lymphoblastoid interferon-alpha.
Zoon KC, et al.
The Journal of Biological Chemistry, 267, 15210-15216 (1992)
Rajani Rajbhandari et al.
Oncotarget, 6(19), 17805-17816 (2015-07-15)
Glioblastomas (GBMs) are deadly tumors of the central nervous system. Most GBM exhibit homozygous deletions of the CDKN2A and CDKN2B tumor suppressors at 9p21.3, although loss of CDKN2A/B alone is insufficient to drive gliomagenesis. MIR31HG, which encodes microRNA-31 (miR-31), is
Yong-Ling He et al.
BioMed research international, 2020, 4757065-4757065 (2020-05-10)
A previous work has discovered that chromosome 1q32 locus linked to the risk of systemic lupus erythematosus (SLE) and miR-181b located on the susceptibility site with downregulation inversely correlating to its target molecular interferon alpha 1 (IFNA1). The purpose of
Marina Juraleviciute et al.
Cancer medicine, 10(8), 2840-2854 (2021-03-19)
MX2 is an interferon inducible gene that is mostly known for its antiviral activity. We have previously demonstrated that MX2 is also associated with the tumorigenesis process in melanoma. However, it remains unknown which molecular mechanisms are regulated by MX2
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