SML1939

SCH 79797 hydrochloride

≥98% (HPLC)

• Szinonimák: N3-Cyclopropyl-7-(4-isopropylbenzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine hydrochloride, N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine hydrochloride, SCH79797 xHCl
• Tapasztalati képlet (Hill-képlet): C₂₃H₂₅N₅ · xHCl
• CAS-szám: 245520-69-8
• Molekulatömeg: 371.48 (free base basis)
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• Forma: powder
• tárolási körülmény: desiccated
• szín: white to light brown
• oldhatóság: DMSO: 2 mg/mL, clear
• tárolási hőmérséklet: room temp
• SMILES string: Cl.Cl.[n]2(c3c(c4c(nc(nc4N)NC5CC5)cc3)cc2)Cc1ccc(cc1)C(C)C
• InChI: 1S/C23H25N5.2ClH/c1-14(2)16-5-3-15(4-6-16)13-28-12-11-18-20(28)10-9-19-21(18)22(24)27-23(26-19)25-17-7-8-17;;/h3-6,9-12,14,17H,7-8,13H2,1-2H3,(H3,24,25,26,27);2*1H
• Nemzetközi kémiai azonosító kulcs: NNJTXSQXGHYXAJ-UHFFFAOYSA-N

Leírás

Biokémiai/fiziológiai hatások

A high affinity non-peptide PAR-1-selective antagonist that inhibits PAR-1-mediated physiological and pathological processes both in vitro and in vivo.

SCH 79797 aids protection during ischemic injury. During subarachnoid hemorrhage (SAH), it plays a key role in the maintenance of microvascular integrity. SCH 79797 also elicits pro‐apoptotic and antiproliferative effects.

SCH 79797 is a nonpeptidic antagonist that targets protease activated receptor-1 (PAR-1) with high affinity (IC50 = 70 nM against 10 nM haTRAP in competitive binding assay; Ki = 35 nM) and selectively inhibits PAR-1 agonists-induced human platelet aggregation (IC50 = 300 nM and 3 μM against 300 nM haTRAP and 0.1 U/mL α-thrombin, respectively), while exhibiting little potency against platelet aggregation induced by ADP, collagen, or PAR-4 agonist γ-thrombin. SCH-79797 is shown to display neuroprotective and antiepileptogenic efficacy in a rat model of lithium/pilocarpine-induced status epilepticus (SE) in vivo (25 μg/kg via daily i.p. 20-30 min after SE termination).

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable