SML1157

Eact

≥98% (HPLC)

• Szinonimák: 3,4,5-Trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)-benzamide
• Tapasztalati képlet (Hill-képlet): C₂₂H₂₄N₂O₅S
• CAS-szám: 461000-66-8
• Molekulatömeg: 428.50
• MDL-szám: MFCD03115431
• UNSPSC kód: 12352200
• PubChem Substance ID: 329825687
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• form: powder
• szín: white to beige
• oldhatóság: DMSO: 20 mg/mL, clear
• tárolási hőmérséklet: 2-8°C
• SMILES string: O=C(C1=CC(OC)=C(OC)C(OC)=C1)N(CCOC)C2=NC(C3=CC=CC=C3)=CS2
• InChI: 1S/C22H24N2O5S/c1-26-11-10-24(22-23-17(14-30-22)15-8-6-5-7-9-15)21(25)16-12-18(27-2)20(29-4)19(13-16)28-3/h5-9,12-14H,10-11H2,1-4H3
• Nemzetközi kémiai azonosító kulcs: ZUXNHFFVQWADJL-UHFFFAOYSA-N

Leírás

Biokémiai/fiziológiai hatások

E_act activates the Calcium-activated Chloride channel (CaCC) TMEM16A CaCC. E_act stimulates CaCC conductance in salivary gland cells and submucosal airway epithelial cells. The compound E_act also stimulates submucosal gland secretion in human bronchial tissue and smooth muscle contraction in mouse intestine.

In rat arterial myocytes, Eact [3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)benzamide] helps to activate chloride current and prevents estradiol synthesis in cultured mouse granulosa cells. It is a small molecule activator of TMEM16A (transmembrane member 16A), that activates TRPV1 (transient receptor potential cation channel subfamily V member 1) and generates pain and itch related symptoms. Eact also initiates endogenous TRPV1 expressed by DRG (dorsal root ganglion) neurons.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable