SAB3500209

Anti-AGTR1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Szinonimák: Anti-AT1, Anti-AT1R, Anti-Ang II, Anti-Angiotensin II receptor type 1
• MDL-szám: MFCD01321727
• UNSPSC kód: 12352203
• NACRES: NA.41
• konjugátum: unconjugated
• application: ELISA (i); IF; IHC; WB
• klón: polyclonal
• faj reaktivitás: rat, human, mouse
• citations: 13
• technika/technikák: immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 100
• konjugátum: unconjugated
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: polyclonal
• Forma: buffered aqueous solution
• faj reaktivitás: rat, human, mouse
• technika/technikák: immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• NCBI elérési szám: EAW78909
• UniProt elérési szám: P30556
• kiszállítva: dry ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... AGTR1(185)

Leírás

Általános leírás

Angiotensin II receptor, type 1 (AGTR1) is a G-protein coupled receptor possessing seven transmembrane functional domains. AGTR1 gene spanning around 45.1kb, with five exons, is located on human chromosome 3q21−q25. AGTR1 is highly expressed on endothelial cells, monocytes, podocytes, renal vascular smooth muscle cells and renal arteries.

Angiotensin II receptor, type 1 or AT1 receptor (AGRR1, AT1R) is a receptor for the vasoconstriction peptide angiotensin II involved in the regulation of cardiovascular effects such as blood vasoconstriction (blood pressure), aldosterone and vasopressin secretion, cardiac hypertrophy, vascular smooth muscle cells proliferation, decreased renal blood flow, renal renin inhibition, renal tubular sodium reuptake, modulation of central sympathetic nervous system activity, cardiac contractility, central osmocontrol and extracellular matrix formation.

Rabbit polyclonal anti-AGTR1 reacts with mouse, human, and rat angiotensin II receptor.

Immunogén

AGTR1 antibody was raised against a 16 amino acid peptide from near the center of human AGTR1.

Alkalmazás

Anti-AGTR1 antibody produced in rabbit has been used in in situ proximity ligation assay (PLA) and immunoblotting.

Rabbit polyclonal anti-AGTR1 is used to tag angiotensin II receptor for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of angiotensin II receptor in the regulation of processes that affect vascular functions such as blood pressure and blood flow.

Biokémiai/fiziológiai hatások

Angiotensin II receptor, type 1 (AGTR1) has a key function in vascular smooth muscle contraction and maintenance of vasopressor effects by controlling aldosterone secretion. The binding of angiotensin II to AGTR1 contributes to the proliferation of vascular smooth muscle cells by the activation of G protein. The binding also results in the activation of Ca²⁺ dependent kinases as IP3 (inositol triphosphate) and MAPK (mitogen-activated protein kinases) for the synthesis of proteins and expression of proto-oncogenes, respectively. AGTR1 is associated with high risk of hypertension and cardiovascular diseases.

Tulajdonságok és előnyök

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Kapcsolódás

The action of this antibody can be blocked using blocking peptide SBP3500209.

Fizikai forma

Supplied in PBS with 0.02% sodium azide.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable