PRS3627

Anti-LAMP-2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Szinonimák: Anti-Lysosomal-associated membrane protein 2
• MDL-szám: MFCD01864612
• UNSPSC kód: 12352203
• NACRES: NA.41
• konjugátum: unconjugated
• application: ELISA (i); ICC; WB
• klón: polyclonal
• faj reaktivitás: mouse, human
• citations: 13
• technika/technikák: immunocytochemistry: suitable; indirect ELISA: suitable; western blot: suitable

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 100
• konjugátum: unconjugated
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: polyclonal
• Forma: buffered aqueous solution
• faj reaktivitás: mouse, human
• technika/technikák: immunocytochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• UniProt elérési szám: P17047
• kiszállítva: dry ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: mouse ... Lamp2(16784)

Leírás

Általános leírás

Lamp2 (lysosome-associated membrane protein gene)is located in the lysosomal lumen and lysosomal membrane. However upon chronic acidosis in the tumour microenvironment, it is found to be present in the plasma membrane.

Immunogén

a 17 amino acid peptide from near the center of human LAMP-2.

Alkalmazás

Anti-LAMP-2 antibody has been used in immunofluorescence and western blot.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Biokémiai/fiziológiai hatások

LAMP2 (lysosome-associated membrane protein gene) preserves lysosomal membranes from acid proteolysis. It serves as an acidity biomarker in spheroids and xenografts. It also has some role in maturation of autophagic vacuoles and cell-cell or cell-extracellular matrix adhesion. Reduction of LAMP2 (lysosome-associated membrane protein gene) can increase acidosis-mediated toxicity. Mutation in LAMP2 can cause cardiomyopathy in young patients.

Kapcsolódás

The action of this antibody can be blocked using blocking peptide SBP3627.

Fizikai forma

Solution in phosphate buffered saline containing 0.02% sodium azide

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable