P3235
Prostate Specific Antigen from human semen
buffered aqueous solution
Szinonimák:
Cancer-associated PSA, PSA
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Javasolt termékek
biológiai forrás
human semen
Minőségi szint
Teszt
≥99% (SDS-GE)
form
buffered aqueous solution
UniProt elérési szám
kiszállítva
wet ice
tárolási hőmérséklet
−20°C
Géninformáció
human ... KLK3(354)
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Általános leírás
Prostate specific antigen (PSA) is a 26kDa single-chain glycoprotein containing 237 amino acids, encoded by the kallikrein gene mapped to human chromosome 19. It is specifically expressed by human prostate tissue and is a highly abundant proteolytic enzyme expressed in the seminal fluid.
Biokémiai/fiziológiai hatások
Prostate Specific Antigen (PSA), a glycoprotein of the glandular kallikrein family, is a serine protease with chymotrypsin-like enzymatic activity. Circulating PSA exists in free and protease inhibitor-bound forms. Studying the ratios of free to inhibitor-bound forms may prove valuable in the diagnosis of prostate cancer.
Prostate-specific antigen (PSA) is an androgen-regulated serine protease specifically produced by prostatic tissue and is secreted into the lumen. PSA in semen cleaves semenogelins present in the seminal coagulum. Total PSA levels are increased in serum of prostate cancer (PCa) patients. PSA functions as a potential biomarker for PCa. Serum protease inhibitors such as α1-antichymotrypsin (α1-ACT), α2-macroglobulin (α2-M) and other acute-phase proteins form irreversible complexes with circulating PSA and hinder proteolytic activity of PSA.
Fizikai forma
Solution in 10 mM Tris, 0.1% sodium azide, pH 8.0
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Az ügyfelek ezeket is megtekintették
Structure, function, and regulation of the enzyme activity of prostate-specific antigen.
Lilja H
World Journal of Urology, 11(4), 188-191 (1993)
D A Armbruster
Clinical chemistry, 39(2), 181-195 (1993-02-01)
Prostate-specific antigen (PSA) is a glycoprotein produced exclusively by prostatic tissue. PSA's absolute tissue specificity makes it valuable as a forensic marker and, more important, as a tumor marker for prostatic cancer. Prostatic cancer is prevalent in the older male
Qian Dang et al.
Analytical and bioanalytical chemistry, 408(25), 7067-7075 (2016-03-05)
A simple and sensitive electrogenerated chemiluminescence biosensor was developed to monitor matrix metalloproteinase 2 (MMP-2) by employing a specific peptide (CGPLGVRGK) as a molecular recognition substrate. Bis(2,2'-bipyridine)-4'-methyl-4-carboxybipyridine-ruthenium N-succinimidyl ester-bis(hexafluorophosphate) (Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 (Ru1) was used as ECL-emitting species and covalently labeled onto
Multiple forms of prostate-specific antigen in serum: differences in immunorecognition by monoclonal and polyclonal assays.
Zhou AM
Clinical Chemistry, 39(12), 2483-2491 (1993)
Steven P Balk et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 21(2), 383-391 (2003-01-15)
Prostate-specific antigen (PSA) is an androgen-regulated serine protease produced by both prostate epithelial cells and prostate cancer (PCa) and is the most commonly used serum marker for cancer. It is a member of the tissue kallikrein family, some of the
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