M1787

Manganese(II) chloride solution

BioReagent, for molecular biology, storage temp.:room temp

• Szinonimák: Manganese chlroide, Manganese(II) chloride, MnCl₂
• Lineáris képlet: MnCl₂
• CAS-szám: 7773-01-5
• Molekulatömeg: 125.84
• MDL-szám: MFCD00011114
• UNSPSC kód: 12352302
• PubChem Substance ID: 24896693
• NACRES: NA.52

Tulajdonságok

• grade: for molecular biology
• Minőségi szint: 200
• sterilitás: 0.2 μm filtered
• termékcsalád: BioReagent
• form: liquid
• koncentráció: 1.00 M±0.01 M
• kation nyomok: heavy metals (as Pb): ≤5 ppm
• idegen aktivitás: DNase, Exonuclease; NICKase, Endonuclease; and protease, none detected
• tárolási hőmérséklet: room temp
• SMILES string: Cl[Mn]Cl
• InChI: 1S/2ClH.Mn/h2*1H;/q;;+2/p-2
• Nemzetközi kémiai azonosító kulcs: GLFNIEUTAYBVOC-UHFFFAOYSA-L

Leírás

Általános leírás

Manganese (II) chloride (MnCl₂) might play a key role in integrin activation. Manganese is indispensable for brain function and is an essential cofactor for several key enzymes like superoxide dismutase and enzymes involved in neurotransmitter synthesis. Manganese can modulate iron and calcium homeostasis. Manganese is also used in the magnetic resonance imaging to increase contrast while examining neuronal connections and brain cytoarchitecture. High levels of manganese is toxic to central nervous system and causes Parkinson′s like symptoms called as manganism. MnCl₂ has been used in reverse transcription reaction mix to enhance the template-switching efficiency.

MnCl₂ solution is a source of manganese ions and has a variety of biological uses. In biochemistry, it can be used as a cofactor in restriction enzymes, such as BamH and EcoR V. In molecular biology, Mn₂⁺ can be substituted for Mg₂⁺ as a divalent metal ion to facilitate DNase I activity in presence of Ca₂⁺.

Alkalmazás

Manganese (II) chloride solution has been used:

• in manganese enhanced magnetic resonance imaging (MEMRI) to study neuronal disease and manganese toxicity
• in high ionic strength reaction mixture to determine RNA polymerase I and II activity
• in reverse transcription reaction mix as a source of Mn₂⁺ ions

Biztonsági adatok

• Piktogramok: GHS08,GHS05,GHS07
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H302,H318,H373
• Óvintézkedésre vonatkozó mondatok: P260 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P314
• Veszélyességi osztályok: Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2
• Célzott szervek: Brain
• Tárolási osztály kódja: 12 - Non Combustible Liquids
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)