Összes fotó(1)
Fontos dokumentumok
M0800
Anti-p38 MAP Kinase antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Szinonimák:
Anti-ERK, Anti-ERK-2, Anti-ERK2, Anti-ERT1, Anti-MAPK2, Anti-NS13, Anti-P42MAPK, Anti-PRKM1, Anti-PRKM2, Anti-p38, Anti-p40, Anti-p41, Anti-p41mapk, Anti-p42-MAPK
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Javasolt termékek
biológiai forrás
rabbit
Minőségi szint
konjugátum
unconjugated
antitest forma
IgG fraction of antiserum
antitest terméktípus
primary antibodies
klón
polyclonal
form
buffered aqueous solution
molekulatömeg
antigen 40 kDa
faj reaktivitás
mouse, rat
technika/technikák
microarray: suitable
western blot: 1:10,000 using NIH3T3 mouse fibroblast lysate and rat brain extract
UniProt elérési szám
kiszállítva
dry ice
tárolási hőmérséklet
−20°C
célzott transzláció utáni módosítás
unmodified
Géninformáció
human ... MAPK1(5594)
mouse ... Mapk1(26413)
rat ... Mapk1(116590)
Általános leírás
P38 MAPK is a mitogen-activated protein kinase (MAPK) that belongs to serine/threonine protein kinases family and is activated in response to stress signals like- osmolarity changes, UV-irradiation, heat shock,cytokines and lipopolysaccharides (LPS). It mainly expresses in brain, muscle, thymus, spleen, heart, lung, kidney and fibroblasts.
Egyediség
Rabbit anti-p38 MAP Kinase antibody reacts specifically with p38 MAP kinase from mouse and rat.
Immunogen
synthetic peptide K-DEVISFVPPPLDQEEMES derived from the C-terminus of mouse p38 MAP kinase (amino acids 343-360 with N-terminally added lysine) as immunogen. This sequence is highly conserved in human and rat p38 MAP kinase.
Alkalmazás
Anti-p38 MAP Kinase antibody has been used in western blotting (diluted 1:1000) using using NIH 3T3 mouse fibroblasts cell lysate and rat brain extract. It has also been used in microarray.
Biokémiai/fiziológiai hatások
Mitogen-activated protein kinases (MAP kinases, MAPKs) are a family of protein kinases which are considered to play a crucial role in signal transduction pathways in mammalian cells by leading mitogenic signals to their intracellular targets. MAP kinases regulate several cellular processes, such as proliferation, differentiation, response to stress and oncogenesis. p38 MAPK is activated in response to stress signals like- osmolarity changes, ultravoilet-irradiation, heat shock, cytokines and lipopolysaccharides (LPS). It is required for phosphorylation of MAPK-activated protein kinase 2 (MAPKAPK-2). Anti-p38 MAP Kinase antibody can be used to study the differential tissue expression, specific activation requirements and intracellular localization of MAP kinase isoforms in normal and neoplastic tissues.
Fizikai forma
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Tárolási osztály kódja
10 - Combustible liquids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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