I2276

Interleukin-12 human

≥97% (SDS-PAGE and N-terminal analysis), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture

• Szinonimák: IL-12
• MDL-szám: MFCD00212975
• UNSPSC kód: 12352202
• NACRES: NA.32

Tulajdonságok

• biológiai forrás: human
• Minőségi szint: 200
• rekombináns: expressed in baculovirus infected Sf21 cells
• Teszt: ≥97% (SDS-PAGE and N-terminal analysis)
• Forma: lyophilized powder
• hatékonyság: 0.01-0.05 ng/mL ED₅₀
• molekulatömeg: glycoprotein 75 kDa
• kiszerelés: pkg of 5 μg
• technika/technikák: cell culture | mammalian: suitable
• szennyeződések: endotoxin, tested
• UniProt elérési szám: P29459,; P29460
• tárolási hőmérséklet: −20°C
• Géninformáció: human ... IL12A(3592) , IL12B(3593)

Leírás

Biokémiai/fiziológiai hatások

Interleukin-12 (IL-12) was identified as a factor secreted by human Epstein-Barr (EBV)-transformed B cell lines. IL-12, or Natural Killer Cell Stimulatory Factor (NKSF), is a 75 kDa disulfide-linked heterodimer of a 35 kDa subunit and 40 kDa subunit. IL-12 is produced predominantly by monocytes and NK cells and induces T cells and NK cells to produce IFN-γ. Human IL-12 is not active on mouse cells, but murine IL-12 is active on both murine and human lymphocytes. The biological activity of recombinant human IL-12 was measured by its ability to stimulate the proliferation of PHA-activated human T lymphoblasts. IL-12 has anti-angiogenic properties.

Fizikai forma

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)