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Merck

I1261

Sigma-Aldrich

Anti-Human IgA (α-chain specific) antibody produced in goat

whole antiserum

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

MDL-szám:
UNSPSC kód:
12352203
NACRES:
NA.46

biológiai forrás

goat

Minőségi szint

konjugátum

unconjugated

antitest forma

whole antiserum

antitest terméktípus

secondary antibodies

klón

polyclonal

tartalmaz

15 mM sodium azide

technika/technikák

indirect ELISA: 1:50,000
quantitative precipitin assay: 3.0-5.0

kiszállítva

dry ice

tárolási hőmérséklet

−20°C

célzott transzláció utáni módosítás

unmodified

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Általános leírás

Immunoglobulin A (IgA) is found as two subclasses, that is, IgA1 and IgA2. IgA exists as a monomer or dimer in the secreted form. Dimeric IgA has a molecular weight of 390 kDa.

Egyediség

The antibody preparation is specific for human IgA when tested against purified human IgA, IgG, IgM, Bence Jones Kappa, and Bence Jones Lambda myeloma proteins

Alkalmazás

Anti-Human IgA (α-chain specific) antibody produced in goat has been used to determine the concentration of total IgA in serum samples by single radial immunodiffusion and enzyme-linked immunosorbent assay (ELISA).

Biokémiai/fiziológiai hatások

IgA antibody is secretory antibody and is present abundantly in mucous linings of gastrointestinal, respiratory and genitourinary tracts, tears and saliva. Thus secretory IgA contributes to the humoral defense mechanism against the pathogens on mucosal surfaces.
In addition to passive immunity, IgA also induces active immunity by regulating the production of various chemokines and vital cytokines such as tumor necrosis factor (TNF) and interleukin (IL)-1β.

Fizikai forma

Goat Anti-Human IgA is supplied as a liquid containing 0.1% sodium azide as preservative.

Tárolás és stabilitás

For continuous use, store at 2-8 °C for a maximum of one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Tárolási osztály kódja

10 - Combustible liquids

WGK

nwg

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable


Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Ivo S Hansen et al.
Cellular and molecular life sciences : CMLS, 76(6), 1041-1055 (2018-12-01)
The prevailing concept regarding the immunological function of immunoglobulin A (IgA) is that it binds to and neutralizes pathogens to prevent infection at mucosal sites of the body. However, recently, it has become clear that in humans IgA is also
Eva Michaud et al.
EMBO molecular medicine, 14(8), e15386-e15386 (2022-07-06)
Human secretory immunoglobulins (SIg) A1 and SIgA2 guide mucosal responses toward tolerance or inflammation, notably through reverse-transcytosis, the apical-to-basal transport of IgA2 immune complexes via M cells of gut Peyer's patches. As such, the maintenance of a diverse gut microbiota
Kinetic Analysis of Interaction of Different Types of Rheumatoid Factors with Immobilized IgG Using Surface PlasmonResonance
Matsumoto A, et al.
The Journal of Biological Chemistry, 128(6), 1009-1016 (2000)
L C Torres et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 43(12), 1215-1224 (2010-11-19)
Rubinstein-Taybi syndrome (RTS) is a rare developmental disorder characterized by craniofacial dysmorphisms, broad thumbs and toes, mental and growth deficiency, and recurrent respiratory infections. RTS has been associated with CREBBP gene mutations, but EP300 gene mutations have recently been reported
Ketil Moen et al.
Clinical and diagnostic laboratory immunology, 10(6), 1043-1050 (2003-11-11)
The objective of the present study was to investigate immunoglobulin G (IgG) and IgA antibody immune responses to Porphyromonas gingivalis, Prevotella intermedia, Bacteroides forsythus, and Candida albicans in the sera of patients with rheumatoid arthritis (RA), the synovial fluid (SF)

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