HPA021451

Anti-SLC16A3 antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• Szinonimák: Anti-MCT 3, Anti-MCT 4, Anti-Monocarboxylate transporter 3, Anti-Monocarboxylate transporter 4, Anti-Solute carrier family 16 member 3
• UNSPSC kód: 12352203
• Human Protein Atlas-szám: HPA021451
• NACRES: NA.41

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 100
• konjugátum: unconjugated
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: polyclonal
• termékcsalád: Prestige Antibodies^® Powered by Atlas Antibodies
• form: buffered aqueous glycerol solution
• faj reaktivitás: rat, human, mouse
• technika/technikák: immunofluorescence: 0.25-2 μg/mL; immunohistochemistry: 1:200-1:500
• immunogén szekvencia: AEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
• UniProt elérési szám: O15427
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... SLC16A3(9123)

Leírás

Általános leírás

The gene SLC16A3 (solute carrier family 16 member 3) is mapped to human chromosome 17q25.3. It belongs to the SLC16A family and is a transmembrane protein. SLC16A3 is expressed in testis, small intestine, lung, brain, heart, kidney, and spleen. SLC16A3 is commonly referred to as MCT4 (monocarboxylate transporter 4).

Immunogen

Monocarboxylate transporter 4 recombinant protein epitope signature tag (PrEST)

Alkalmazás

Anti-SLC16A3 antibody produced in rabbit has been used in: immunohistochemistry, flow cytometry, and immunofluorescence (IF) confocal microscopy to stain human bronchial epithelial cells (HBECs)-short hairpin RNA (shRNA) targeting TP53(shp53 (shp53)-V5-TMPRSS11B cells.

Biokémiai/fiziológiai hatások

MCTs (monocarboxylate transporters) are important for transporting lactate and other monocarboxylates across the cell membrane. MCT4/SLC16A3 (solute carrier family 16 member 3) is involved in the transport of γ-hydroxybutyric acid and L-lactate. SLC16A3 is up-regulated in triple negative breast cancer. It is responsible for maintenance of pH, lactate secretion and non-oxidative metabolism of glucose in cancer cells. In similar manner, androgens induce glycolytic metabolism and lactate export in prostate cancer cells by regulating SLC16A3 expression.

Tulajdonságok és előnyök

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Kapcsolódás

Corresponding Antigen APREST75671

Fizikai forma

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Jogi információk

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 1