Összes fotó(1)
Fontos dokumentumok
C7048
Monoclonal Anti-CD3 antibody produced in mouse
clone UCHT-1, purified immunoglobulin, buffered aqueous solution
Szinonimák:
Monoclonal Anti-CD3
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
UNSPSC kód:
12352203
NACRES:
NA.41
konjugátum:
unconjugated
application:
FACS
klón:
UCHT-1, monoclonal
faj reaktivitás:
human
citations:
9
technika/technikák:
flow cytometry: 5 μL using 1 × 106 cells
Javasolt termékek
biológiai forrás
mouse
Minőségi szint
konjugátum
unconjugated
antitest forma
purified immunoglobulin
antitest terméktípus
primary antibodies
klón
UCHT-1, monoclonal
Forma
buffered aqueous solution
faj reaktivitás
human
technika/technikák
flow cytometry: 5 μL using 1 × 106 cells
izotípus
IgG1
UniProt elérési szám
kiszállítva
wet ice
tárolási hőmérséklet
2-8°C
célzott transzláció utáni módosítás
unmodified
Géninformáció
human ... CD3E(916)
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Egyediség
Recognizes the CD3 complex. The epitope recognized by clone no. UCHT-1 is expressed on the ε-chain of the CD3 antigen/T cell receptor complex. 3rd Workshop: code no. 126, 208 and 471
4th Workshop: paper no. T3.2
4th Workshop: paper no. T3.2
Immunogén
human thymocytes followed by Sezary T cells.
Alkalmazás
Monoclonal Anti-CD3 antibody produced in mouse is suitable for flow cytometry at a dilution of 5μL using 1 × 106 cells.
Biokémiai/fiziológiai hatások
The CD3e cytoplasmic domain of the T cell receptor binds to the inner leaflet of the plasma membrane (PM) and is accessible during early stages of T cell activation. It is specific for T lymphocytes, found in Purkinje cells of the cerebellum and gastric parietal cells of humans and other species. The antibodies commonly used to recognize CD3 are directed against the ε-subunit of the T cell receptor. Cytoplasmic cyCD3 expression can only be achieved during the early phase of NK-cell differentiation.
Cél megnevezése
The CD3 complex (16/20/29/22/25-28 kDa) consists of 5 polypeptide chains associated with each other and with the T cell receptor.
Fizikai forma
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Tárolási osztály kódja
10 - Combustible liquids
WGK
nwg
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Francesco Dieli et al.
The Journal of infectious diseases, 186(12), 1835-1839 (2002-11-26)
Vgamma9/Vdelta2 T cells can contribute to protective immune response against Mycobacterium tuberculosis, although the extent to which and mechanisms by which they could actually protect against human tuberculosis remain unclear. We have previously reported that Vgamma9/Vdelta2 T cells from tuberculin
Graeme O'Boyle et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(12), 4598-4603 (2012-03-07)
The recruitment of T lymphocytes during diseases such as rheumatoid arthritis is regulated by stimulation of the chemokine receptors expressed by these cells. This study was designed to assess the potential of a CXCR3-specific small-molecule agonist to inhibit the migration
F Dieli et al.
The Journal of infectious diseases, 181(1), 294-301 (1999-12-23)
The alphabeta and gammadelta T cell responses were analyzed in the peripheral blood of children affected by active tuberculosis (TB) and in healthy children who tested positive (PPD+) or negative (PPD-) for purified protein derivative. PPD+ healthy and diseased children
Bernd Schlereth et al.
Cancer research, 65(7), 2882-2889 (2005-04-05)
Bispecific T-cell engager (BiTE) are a class of bispecific single-chain antibodies that can very effectively redirect cytotoxic T cells for killing of tumor target cells. Here, we have assessed the in vivo efficacy of one representative, called bscEp-CAMxCD3, with specificity
A Greiner et al.
Developmental immunology, 6(3-4), 187-195 (1998-11-14)
Low-grade MALT-type lymphomas are malignancies of mucosal marginal-zone B cells and preceded by reactive inflammatory lymphoid tissue. Experimental observations suggest that antigen and CD40 Ligand act during cognate T/B cell interaction and are crucial for germinal center B-cell maturation generating
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