B3428
Anti-Bax antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Szinonimák:
Anti-BCL2L4
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)
About This Item
konjugátum:
unconjugated
application:
ARR
WB
WB
klón:
polyclonal
faj reaktivitás:
human, rat, mouse
citations:
29
technika/technikák:
microarray: suitable
western blot: 1:2,000 using whole cell extract of MCF7 human breast adenocarcinoma cell line
western blot: 1:2,000 using whole cell extract of MCF7 human breast adenocarcinoma cell line
Javasolt termékek
biológiai forrás
rabbit
Minőségi szint
konjugátum
unconjugated
antitest forma
IgG fraction of antiserum
antitest terméktípus
primary antibodies
klón
polyclonal
Forma
buffered aqueous solution
molekulatömeg
antigen 23 kDa
faj reaktivitás
human, rat, mouse
technika/technikák
microarray: suitable
western blot: 1:2,000 using whole cell extract of MCF7 human breast adenocarcinoma cell line
UniProt elérési szám
kiszállítva
dry ice
tárolási hőmérséklet
−20°C
célzott transzláció utáni módosítás
unmodified
Géninformáció
human ... BAX(581)
mouse ... Bax(12028)
rat ... Bax(24887)
Általános leírás
Bax is a 21kD integral organelle membrane protein that belongs to the Bcl-2 family and is expressed mainly in the mitochondria. It exist in three cytosolic forms Bax β (24 kDa), Bax γ (5 kDa) and Bax δ (16 kDa) generated by alternative splicing.
Immunogén
synthetic peptide GGPTSSEQIMKTGALLLQGF-K corres- ponding to the N-terminal region of Bax of human origin (Bax α, amino acids 11-30 with C-terminally added lysine), conjugated to KLH as immunogen. This sequence is identical in human Bax β and highly conserved in rat and mouse Bax α (single amino acid substitution) and human Bax.
Alkalmazás
Anti-BMPR2 (836-850) antibody produced in rabbit is suitable for western blotting at a concentration of 1:500-1:2,000.
Biokémiai/fiziológiai hatások
BAX is a proapoptotic protein that forms homodimer to accelerate apoptotic death whereas its heterodimerization with Bcl-2 or Bcl-xL can block apoptosis. BAX binds to the mitochondrial permeability transition pore complex (PTPC), and when expressed in cells, it induces mitochondrial dysfunction and the release of cytochrome C, leading to activation of caspases and triggers apoptosis. Loss-of-function mutation in the BAX gene results in Hematopoietic malignancies.
Fizikai forma
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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javasolt
Tárolási osztály kódja
10 - Combustible liquids
WGK
nwg
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Az ügyfelek ezeket is megtekintették
Jonathan M Greene et al.
Reproductive biology and endocrinology : RB&E, 11, 15-15 (2013-02-28)
L-arginine is considered to be one of the most versatile amino acids due to the fact that it serves as a precursor for many important molecules in cellular physiology. When supplemented in the diet, L-arginine can increase the number of
Satabdi Datta et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 39(2), 1010428317694314-1010428317694314 (2017-02-28)
Paclitaxel (Tx) is one of the first-line chemotherapeutic drugs used against lung cancer, but acquired resistance to this drug is a major challenge against successful chemotherapy. In this work, we have focused on the chronological changes of various cellular parameters
P H Schlesinger et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(21), 11357-11362 (1997-10-23)
The BCL-2 family of proteins is composed of both pro- and antiapoptotic regulators, although its most critical biochemical functions remain uncertain. The structural similarity between the BCL-XL monomer and several ion-pore-forming bacterial toxins has prompted electrophysiologic studies. Both BAX and
J M Jürgensmeier et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(9), 4997-5002 (1998-06-06)
Bax is a pro-apoptotic member of the Bcl-2 protein family that resides in the outer mitochondrial membrane. It is controversial whether Bax promotes cell death directly through its putative function as a channel protein versus indirectly by inhibiting cellular regulators
Sheila J Semaan et al.
ASN neuro, 2(2), e00032-e00032 (2010-04-03)
Pro-apoptotic Bax is essential for RGC (retinal ganglion cell) death. Gene dosage experiments in mice, yielding a single wild-type Bax allele, indicated that genetic background was able to influence the cell death phenotype. DBA/2J(Bax+/-) mice exhibited complete resistance to nerve
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