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Merck
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Fontos dokumentumok

ABC11

Sigma-Aldrich

Anti-Bax (NT) Antibody

from rabbit

Szinonimák:

BCL2-associated X protein, Bcl-2-like protein 4, apoptosis regulator BAX

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(4)

About This Item

UNSPSC kód:
12352203
eCl@ss:
32160702
NACRES:
NA.41
klón:
polyclonal
application:
ICC
IHC
IP
WB
faj reaktivitás:
human
technika/technikák:
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
citations:
17

biológiai forrás

rabbit

Minőségi szint

100

antitest forma

purified antibody

antitest terméktípus

primary antibodies

klón

polyclonal

faj reaktivitás

human

faj reaktivitás (homológia által előrejelzett)

bovine (based on 100% sequence homology), feline (based on 100% sequence homology), canine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology)

technika/technikák

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI elérési szám

NP_620119

UniProt elérési szám

Q07812

kiszállítva

wet ice

célzott transzláció utáni módosítás

unmodified

Géninformáció

human ... BAX(581)

Általános leírás

BAX (BCL2-associated X protein) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAX protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
The previously assigned protein identifier Q07815 has been merged into Q07812. Full details can be found on the UniProt database.

Egyediség

Rat (90%), Mouse (86%).
This antibody recognizes BAX.

Immunogén

KLH-conjugated linear peptide corresponding to human BAX at and around the N-terminus.

Alkalmazás

Anti-Bax Antibody is an antibody against Bax (N-terminus) for use in WB, IP, IC, IH.
Immunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated BAX from 500 µg of HL60 cell lysate.

Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected BAX in colorectal and ductal carcinoma tissue.

Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected BAX in MCF7 cells.

Minőség

Evaluated by Western Blot in HL60 cell lysate.

Western Blot Analysis: 0.125 µg/ml of this antibody detected BAX on 10 µg of HL60 cell lysate.

Cél megnevezése

~ 21 kDa

Kapcsolódás

Replaces: 06-499

Fizikai forma

Format: Purified

Egyéb megjegyzések

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Tárolási osztály kódja

12 - Non Combustible Liquids

WGK

WGK 1

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Dan-Dan Sun et al.
Journal of dental sciences, 18(1), 310-321 (2023-01-17)
Periodontitis is a prevalent infectious inflammatory disease. Growing evidence has revealed important roles for circular RNAs (circRNAs) and circRNA sponge activity in periodontitis. Here, we elucidated the precise part of circ_0097010 in periodontitis pathogenesis. Human periodontal ligament cells (hPDLCs) were
Teruyoshi Saito et al.
Oncology reports, 29(1), 335-342 (2012-11-06)
Hyaluronan (HA), a major component of the extracellular matrix (ECM), is synthesized by HA synthase (HAS) 1, HAS2 and HAS3 and is intricately involved
Adeline Y Robin et al.
Structure (London, England : 1993), 26(10), 1346-1359 (2018-08-21)
BAX and BAK are essential mediators of intrinsic apoptosis that permeabilize the mitochondrial outer membrane. BAX activation requires its translocation from cytosol to mitochondria where conformational changes cause its oligomerization. To better understand the critical step of translocation, we examined
Cristiano Guttà et al.
Cell death & disease, 11(2), 124-124 (2020-02-15)
Despite the introduction of novel targeted therapies, chemotherapy still remains the primary treatment for metastatic melanoma in poorly funded healthcare environments or in case of disease relapse, with no reliable molecular markers for progression-free survival (PFS) available. As chemotherapy primarily
Bo Zhou et al.
Cell research, 28(12), 1171-1185 (2018-10-06)
Iron has been shown to trigger oxidative stress by elevating reactive oxygen species (ROS) and to participate in different modes of cell death, such as ferroptosis, apoptosis and necroptosis. However, whether iron-elevated ROS is also linked to pyroptosis has not
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