Ugrás a tartalomra
Merck

A5971

Sigma-Aldrich

Anti-Water Channel Aquaporin 4 antibody produced in rabbit

lyophilized powder, affinity isolated antibody

Szinonimák:

Anti-AQP4, Anti-Mercurial-Insensitive Water Channel, Anti-WCH4

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

MDL-szám:
UNSPSC kód:
12352203
NACRES:
NA.41

biológiai forrás

rabbit

Minőségi szint

konjugátum

unconjugated

antitest forma

affinity isolated antibody

antitest terméktípus

primary antibodies

klón

polyclonal

form

lyophilized powder

faj reaktivitás

human, mouse, rat

technika/technikák

flow cytometry: suitable (indirect)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

UniProt elérési szám

tárolási hőmérséklet

−20°C

célzott transzláció utáni módosítás

unmodified

Géninformáció

human ... AQP4(361)
mouse ... Aqp4(11829)
rat ... Aqp4(25293)

Általános leírás

AQP4 is an osmoreceptor that regulates water flow in the CNS. It is abundant in astrocytes, but is also weakly noticeable in pulmonary, intestinal, ocular and renal tissues. Rabbit Anti-Water Channel Aquaporin 4 antibody recognizes aquaporin 4 in human, mice and rats.

Immunogen

recombinant fusion protein corresponding to residues 249-323 of rat AQP4 fused to GST.

Alkalmazás

Rabbit Anti-Water Channel Aquaporin 4 antibody can be used for immunohistochemical applications. The antibody can also be used for immunocytochemistry, western blot and flow cytometry applications.

Biokémiai/fiziológiai hatások

Immunoprecipation and western blot analysis using HEK-293 cells that had been transfected with GFP-AQP4 was performed using rabbit anti-AQP4 as the primary antibody at 2μl/ml.

Fizikai forma

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable


Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Michelle Figueroa et al.
JAMA neurology, 71(4), 495-498 (2014-04-16)
Reports of neuromyelitis optica spectrum disorder (NMOSD) occurring in the setting of neoplasia suggest that aquaporin-4 autoimmunity may in some cases have a paraneoplastic basis. In this case report, we describe a patient with NMOSD whose test results were seropositive
Gry Fluge Vindedal et al.
Molecular and cellular neurosciences, 77, 47-52 (2016-11-05)
There is a constitutive production of water in brain. The efflux routes of this excess water remain to be identified. We used basal brain water content as a proxy for the capacity of water exit routes. Basal brain water content
Paraneoplastic Neuromyelitis Optica Associated with Lung Adenocarcinoma in a Young Woman.
Kyoung Won Baik et al.
Journal of clinical neurology (Seoul, Korea), 14(2), 246-247 (2018-04-10)
Vanda A Lennon et al.
The Journal of experimental medicine, 202(4), 473-477 (2005-08-10)
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord. It is considered a severe variant of multiple sclerosis (MS), and frequently is misdiagnosed as MS, but prognosis and optimal treatments differ. A serum
Charles L Howe et al.
Glia, 62(5), 692-708 (2014-02-05)
Neuromyelitis optica (NMO) is a primary astrocyte disease associated with central nervous system inflammation, demyelination, and tissue injury. Brain lesions are frequently observed in regions enriched in expression of the aquaporin-4 (AQP4) water channel, an antigenic target of the NMO

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