A4941

Activin A human

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture

• Szinonimák: Activin A Protein, Growth Factor, Human Growth Factor
• EC-szám: 201-069-1
• MDL-szám: MFCD02685750
• UNSPSC kód: 12352202
• NACRES: NA.32

Tulajdonságok

• product name: Activin A human, ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture
• biológiai forrás: human
• Minőségi szint: 200
• rekombináns: expressed in baculovirus infected insect cells
• Teszt: ≥95% (SDS-PAGE)
• form: lyophilized powder
• hatékonyság: 1-10 ng/mL ED₅₀
• molekulatömeg: dimer 26 kDa (containing 116 amino acid residues βA subunits)
• kiszerelés: pkg of 10 μg; pkg of 5 μg
• technika/technikák: cell culture | mammalian: suitable
• szennyeződések: endotoxin, tested
• UniProt elérési szám: P08476
• tárolási hőmérséklet: −20°C
• Géninformáció: human ... INHBA(3624)

Leírás

Általános leírás

Activin A gene with two exons is mapped to human chromosome 2q35. Activin A also known as inhibin α-subunit belongs to the TGF-β (transforming growth factor-β) superfamily of proteins and its expression is exclusive to gonads, placenta and adrenal cortex.

Alkalmazás

Activin A human has been used as a constituent of modified barth′s saline used in in vitro induction of pronephros. It has also been used as a constituent of Roswell Park memorial institute (RPMI) media to induce pancreatic differentiation of multipotent dermal fibroblasts in vitro.

Biokémiai/fiziológiai hatások

Activins play a vital role in the regulation of hormonogenesis, cellular homeostasis and differentiation programs. Elevated expression of activin A and B leads to the loss of muscle mass. Both activin A and B have a potential to act as a serum markers of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).

Fizikai forma

Lyophilized from 0.2 μm filtered solution in 10 mM sodium citrate, pH 3.0.

Analízis megjegyzés

The biological activity is determined by its ability to inhibit the proliferation of mouse MPC-11 cells.

Biztonsági adatok

• Piktogramok: GHS07
• Figyelmeztetés: Warning
• Figyelmeztető mondatok: H319,H335
• Óvintézkedésre vonatkozó mondatok: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Veszélyességi osztályok: Eye Irrit. 2 - STOT SE 3
• Célzott szervek: Respiratory system
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable