C9774

Cholecalciferol

analytical standard

• Szinonimák: (+)-Vitamin D₃, 7-Dehydrocholesterol activated, Activated 7-dehydrocholesterol, Calciol
• Tapasztalati képlet (Hill-képlet): C₂₇H₄₄O
• CAS-szám: 67-97-0
• Molekulatömeg: 384.64
• Beilstein: 2339331
• EC-szám: 200-673-2
• MDL-szám: MFCD00078131
• UNSPSC kód: 12352205
• eCl@ss: 34058003
• PubChem Substance ID: 24893197
• NACRES: NA.77

Tulajdonságok

• biológiai forrás: synthetic (organic - wool)
• Minőségi szint: 200
• grade: analytical standard
• Teszt: ≥97.0%
• form: crystalline
• kiszerelés: pkg of 250 mg
• szín: white
• mp: 83-86 °C (lit.)
• tárolási hőmérséklet: 2-8°C
• SMILES string: CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C
• InChI: 1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
• Nemzetközi kémiai azonosító kulcs: QYSXJUFSXHHAJI-YRZJJWOYSA-N
• Géninformáció: human ... VDR(7421)

Leírás

Általános leírás

Cholecalciferol, also called vitamin D₃, promotes the absorption of calcium and phosphorus in the body to regulate bone growth. It is most commonly found in humans and animals and is produced in our skin when exposed to sunlight. It is used to treat and prevent bone disorders (such as rickets, osteomalacia).

Alkalmazás

Cholecalciferol has been used as an internal standard in high-performance liquid chromatography (HPLC) to analyze serum vitamin D levels. It has also been used as a standard in liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) to quantify vitamin D3 in sunflower oil.

Cholecalciferol may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.

Biokémiai/fiziológiai hatások

Cholecalciferol is sourced either through the diet or exposing skin to ultraviolet rays. Oral administration of vitamin D3 is readily absorbed and is stored in adipose tissue. Deficiency of vitamin D is often observed in chronic kidney disease.

Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

Kiszerelés

Packaged in flame-sealed ampules under Argon

Biztonsági adatok

• Piktogramok: GHS06,GHS08
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H300 + H310 + H330,H372
• Óvintézkedésre vonatkozó mondatok: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
• Veszélyességi osztályok: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral
• Tárolási osztály kódja: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges