C1200000

Chloramphenicol

European Pharmacopoeia (EP) Reference Standard

• Szinonimák: D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide, D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol, D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide, Chloromycetin
• Lineáris képlet: Cl₂CHCONHCH(CH₂OH)CH(OH)C₆H₄NO₂
• CAS-szám: 56-75-7
• Molekulatömeg: 323.13
• Beilstein: 2225532
• MDL-szám: MFCD00078159
• UNSPSC kód: 41116107
• PubChem Substance ID: 329774875
• NACRES: NA.24

Tulajdonságok

• grade: pharmaceutical primary standard
• API-család: chloramphenicol
• gyártó/kereskedő neve: EDQM
• mp: 149-153 °C (lit.)
• alkalmazás(ok): pharmaceutical (small molecule)
• Formátum: neat
• SMILES string: OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O
• InChI: 1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
• Nemzetközi kémiai azonosító kulcs: WIIZWVCIJKGZOK-RKDXNWHRSA-N

Leírás

Általános leírás

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Alkalmazás

Chloramphenicol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biokémiai/fiziológiai hatások

Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.

Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.

Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.

Kiszerelés

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Egyéb megjegyzések

Sales restrictions may apply.

Biztonsági adatok

• Piktogramok: GHS08,GHS05
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H318,H351,H361fd
• Óvintézkedésre vonatkozó mondatok: P202 - P280 - P305 + P351 + P338 - P308 + P313 - P405 - P501
• Veszélyességi osztályok: Carc. 2 - Eye Dam. 1 - Repr. 2
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3