MAB4418
Anti-Achaete Scute homolog 2 Antibody, clone 7E2
clone 7E2, from mouse
Szinonimák:
achaete-scute complex (Drosophila) homolog-like 2, achaete-scute complex homolog 2 (Drosophila), achaete-scute complex homolog-like 2, achaete-scute complex-like 2, achaete-scute complex-like 2 (Drosophila), mammalian achaete/scute homologue 2
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
UNSPSC kód:
12352203
eCl@ss:
32160702
NACRES:
NA.41
klón:
7E2, monoclonal
application:
ChIP
ICC
WB
ICC
WB
faj reaktivitás:
human
technika/technikák:
ChIP: suitable
immunocytochemistry: suitable
western blot: suitable
immunocytochemistry: suitable
western blot: suitable
citations:
11
Javasolt termékek
biológiai forrás
mouse
Minőségi szint
antitest forma
purified immunoglobulin
antitest terméktípus
primary antibodies
klón
7E2, monoclonal
faj reaktivitás
human
technika/technikák
ChIP: suitable
immunocytochemistry: suitable
western blot: suitable
izotípus
IgG2bκ
NCBI elérési szám
UniProt elérési szám
kiszállítva
wet ice
célzott transzláció utáni módosítás
unmodified
Géninformáció
human ... ASCL2(430)
Általános leírás
Achaete Scute homolog 2 (also known as mammalian aschaete-scute homolog 2 or Mash2) is a nuclear protein expressed specifically in the extravillous trophoblasts of developing placenta. Placental development involves control by the basic helix-loop-helix transcription factor Achaete Scute homolog 2, which may regulate HIF (hypoxia) in the formation of spongiotrophoblasts. Targeted mutagenesis of Achaete Scute homolog 2 yielded loss of function results in embryonic lethality at midgestation due to placental failure associated with a lack of spongiotrophoblasts and reduced labyrinthine trophoblast layers. In addition to healthy placental development, Achaete Scute proteins may also be involved in the determination of neuronal precursors in the central and peripheral nervous systems. Achaete Scute homolog 2 has also been implicated as a controller of intestinal stem cell fate and is essential for the maintenance of adult intestinal stem cells (Tanaka, M., et al., (1997) Dev Biol. 190(10):55-65).
Egyediség
This antibody recognizes Achaete Scute homolog 2 near the C-terminus.
Immunogén
His-tagged recombinant protein corresponding to human Achaete Scute homolog 2 near the C-terminus.
Alkalmazás
Anti-Achaete Scute homolog 2 Antibody, clone 7E2 detects level of Achaete Scute homolog 2 & has been published & validated for use in WB, IC, ChIP.
Immunocytochemmistry Analysis: A previous lot was used by an independent laboratory in IC (Van de Flier, L.G., et al., 2009)
Chromatin Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in ChIP (Hatzis, P., et al., 2008).
Chromatin Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in ChIP (Hatzis, P., et al., 2008).
Minőség
Evaluated by Western Blot in human placenta tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Achaete Scute homolog 2 in 10 µg of human placenta tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Achaete Scute homolog 2 in 10 µg of human placenta tissue lysate.
Cél megnevezése
~20 kDa
Fizikai forma
Format: Purified
Egyéb megjegyzések
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Tárolási osztály kódja
12 - Non Combustible Liquids
WGK
WGK 1
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.
Jun Ye et al.
Cell cycle (Georgetown, Tex.), 17(8), 1014-1025 (2018-06-12)
The Wnt signaling pathway controls stem cell identity in the intestinal epithelium and cancer stem cells (CSCs). The transcription factor Ascl2 (Wnt target gene) is fate decider of intestinal cryptic stem cells and colon cancer stem cells. It is unclear
Genta Nagae et al.
Nature communications, 12(1), 5423-5423 (2021-09-21)
Hepatoblastoma (HB) is the most common pediatric liver malignancy; however, hereditary predisposition and acquired molecular aberrations related to HB clinicopathological diversity are not well understood. Here, we perform an integrative genomic profiling of 163 pediatric liver tumors (154 HBs and
Jarom Heijmans et al.
Cell reports, 3(4), 1128-1139 (2013-04-03)
Stem cells generate rapidly dividing transit-amplifying cells that have lost the capacity for self-renewal but cycle for a number of times until they exit the cell cycle and undergo terminal differentiation. We know very little of the type of signals
Yangyang Shang et al.
Oncotarget, 6(31), 30993-31006 (2015-08-27)
The role of Achaete scute-like 2 (Ascl2) in colorectal cancer (CRC) cell differentiation is unknown. LS174T, HT-29 and Caco-2 cells have high Ascl2 expression, while Lovo and SW480 cells have low Ascl2 expression. LS174T and HT-29 cells with Ascl2 knockdown
Zhongfeng Liu et al.
Aging and disease, 10(6), 1207-1220 (2019-12-04)
The molecular mediators underlying the effects of inflammation on neural stem cells (NSCs) are not fully characterized. In this study, we identified Ascl2 as a downstream basic helix-loop-helix (bHLH) transcription factor in NSCs following exposure to TNFα. Under normal conditions
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