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Merck
Összes fotó(1)

Fontos dokumentumok

AG968

Sigma-Aldrich

β Amyloid 1-42, aβ, ultra pure, HFIP, recombinant human

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)

About This Item

UNSPSC kód:
12352202
eCl@ss:
32160405
NACRES:
NA.41

biológiai forrás

human

Minőségi szint

100

Teszt

>97.0%

form

powder

gyártó/kereskedő neve

Chemicon®

NCBI elérési szám

NM_000484.2
NM_201413.1
NM_201414.1

UniProt elérési szám

P05067

Géninformáció

human ... APP(351)

Általános leírás

β Amyloid 1-42 is a derivative of integral membrane-bound amyloid precursor protein. It is the most important alloform of the Alzheimer′s peptide.

Alkalmazás

β Amyloid 1-42, aβ, ultra-pure, HFIP, recombinant human has been used:
  • to study its effect on the activity of mitochondrial BKCa (mitoBKCa) channels in human astrocytoma cells through patch-clamp technique
  • to study its effect on alteration in protein levels of dystrophic neurites (DNs) forming proteins in mouse neuroblastoma cells
  • to induce Alzheimer′s disease in a rat model for experimental studies

Biokémiai/fiziológiai hatások

β Amyloid 1-42 causes neurotoxicity and is implicated in the pathogenesis of Alzheimer′s disease (AD). β Amyloid (βA) acts as a ligand for several receptors and other molecules involved in complex trafficking pathways in tissues and blood-brain barriers. βA along with amylin elevates cyclic adenosine monophosphate (cAMP) and Ca2+ in turn activates multiple signaling pathway mediators like mitogen-activated protein kinase (MAPK), protein kinase A/B, and cFOS. It acts as the main source of AD-associated neuroinflammation.

Jogi információk

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Tárolási osztály kódja

13 - Non Combustible Solids

WGK

WGK 1

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

Már rendelkezik ezzel a termékkel?

Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Annika Olsson et al.
Clinical chemistry, 51(2), 336-345 (2004-11-26)
To simultaneously study several biomarkers for Alzheimer disease (AD), we used the xMAP technology to develop and evaluate a multiparametric bead-based assay for quantification of beta-amyloid((1-42)) [Abeta((1-42))], total tau (T-TAU), and hyperphosphorylated tau [P-TAU((181P))] in cerebrospinal fluid (CSF). We compared
Stephanie J Soscia et al.
PloS one, 5(3), e9505-e9505 (2010-03-09)
The amyloid beta-protein (Abeta) is believed to be the key mediator of Alzheimer's disease (AD) pathology. Abeta is most often characterized as an incidental catabolic byproduct that lacks a normal physiological role. However, Abeta has been shown to be a
Mohabbat Ahmadi et al.
Avicenna journal of phytomedicine, 9(5), 465-473 (2019-09-14)
Zataria multiflora (ZM) is a plant with ethnopharmacological value which was recently tested to reduce symptoms of Alzheimer's disease (AD). The aim of the present study was to determine the effect of ZM essential oil on spatial cognitive and noncognitive
Ye Ji Lee et al.
Frontiers in molecular neuroscience, 16, 1150399-1150399 (2023-05-05)
Growth-associated protein 43 (GAP-43) is known as a neuronal plasticity protein because it is widely expressed at high levels in neuronal growth cones during axonal regeneration. GAP-43 expressed in mature adult neurons is functionally important for the neuronal communication of
Akiko Amano et al.
Journal of nanobiotechnology, 21(1), 36-36 (2023-02-02)
Although a large amount of evidence has revealed that amyloid β (Aβ), especially Aβ oligomers, protofibrils, and pyroglutamated Aβs, participate primarily in the pathophysiological processes of Alzheimer's disease, most clinical trials of anti-Aβ antibody therapy have never acquired successful efficacy
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