8.55008

Sieber Amide resin

Novabiochem^®

• Szinonimák: Sieber Amide resin, 9-Fmoc-amino-xanthen-3-yloxy-Merrifield resin
• CAS-szám: 915706-90-0
• MDL-szám: MFCD00039239
• UNSPSC kód: 12352111
• NACRES: NA.22

Tulajdonságok

• Minőségi szint: 400
• termékcsalád: Novabiochem^®
• Forma: beads
• reakcióalkalmasság: reaction type: Fmoc solid-phase peptide synthesis
• gyártó/kereskedő neve: Novabiochem^®
• alkalmazás(ok): peptide synthesis
• funkcionális csoport: amine
• tárolási hőmérséklet: 2-8°C

Leírás

Általános leírás

A hyper acid-labile resin for the Fmoc SPPS of protected peptide amides via mild 1% TFA cleavage ^[1,2]. The resin can be readily reductively alkylated to provide a support suited to the synthesis of secondary carboxamides ^[3].This resin has also been employed to produce protected peptide fragments in which the C-terminal carboxylic acid group is blocked as a hydroxymethylphenoxy-β-alaninamide ester ^[4] .

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Alkalmazás

• Determining the Hydrophobicity Index of Protected Amino Acids and Common Protecting Groups: Discusses the synthesis of peptide sequences using Sieber Amide resin for its acid-labile properties. (Gavva et al., 2023).
• Smart biomaterials: Surfaces functionalized with proteolytically stable osteoblast-adhesive peptides: Utilizes Sieber Amide resin for surface functionalization techniques in biomaterials. (Zamuner et al., 2017).
• A 99mTc-tricine-HYNIC-labeled peptide targeting the melanocortin-1 receptor for melanoma imaging: Describes the use of Sieber Amide resin in the synthesis of radiolabeled peptides for diagnostic imaging. (Shamshirian et al., 2016).

Kapcsolódás

Replaces: 01-64-0059

Analízis megjegyzés

Color (visual): white to light yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.80 mmol/g
Swelling Volume (in DMF): lot specific result
Swelling Volume (in CH₂Cl₂): lot specific result
Total swelling volume acc. Houben Weyl (in CH₂Cl₂): ≥ 5.2 ml/g
Total swelling volume acc. Houben Weyl (in DMF): ≥ 5.2 ml/g
The polymer matrix is copoly (styrene - 1% DVB) 100 -200 mesh

Jogi információk

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable