565784-M

γ-Secretase Inhibitor IX

≥95% (HPLC), liquid, γ-secretase inhibitor, Calbiochem^®

• Szinonimák: InSolution γ-Secretase Inhibitor IX, N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT
• Tapasztalati képlet (Hill-képlet): C₂₃H₂₆F₂N₂O₄
• Molekulatömeg: 432.46
• UNSPSC kód: 12352200

Tulajdonságok

• product name: γ-Secretase Inhibitor IX, InSolution, ≥95%, 25 mM, g-secretase Inhibitor IX
• Minőségi szint: 100
• Teszt: ≥95% (HPLC)
• form: liquid
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; desiccated (hygroscopic); protect from light
• szín: clear colorless
• tárolási hőmérséklet: 2-8°C

Leírás

Általános leírás

A cell-permeable dipeptide that inhibits γ-secretase activity and suppresses Aβ production (Aβ total IC₅₀ = 115 nM; Aβ₄₂ IC₅₀ = 200 nM). Reported to be functionally active in both HEK293 cells overexpressing human APP751 and neuronal cultures, however, it does not affect the secretion of amyloid-b precursor protein (APP). Effective in acutely lowering Ab in APPV717F-transgenic mice. Also effective in inhibiting the production of a ~6 kDa C-terminal cleavage product (CTFg) in HEK293 cells stably transfected with the Swedish mutant, βAPP₆₉₅. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice.

Biokémiai/fiziológiai hatások

Primary Target
Aβ_total

Target IC₅₀: 115 nM, 200 nM against Aβ_total, Aβ42, respectively

Figyelmeztetés

Toxicity: Irritant (B)

Fizikai forma

A 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565770) in DMSO.

Feloldás

Following initial use, aliquot and freeze (-20°C).

Egyéb megjegyzések

Oddo, S., et al. 2004. Neuron43, 321.
Dovey, H.F., et al. 2001. J. Neurochem.76, 173.
Vandermeeren, M., et al. 2001. Neurosci. Lett.315, 145.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 2
• Lobbanási pont (F): 188.6 °F - closed cup - (refers to pure substance)
• Lobbanási pont (C): 87 °C - closed cup - (refers to pure substance)