196878-M

(±)-Bay K 8644

Synthetic dihydropyridine derivative that acts as an active Ca²⁺ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types.

• Szinonimák: (±)-Bay K 8644, 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester
• Tapasztalati képlet (Hill-képlet): C₁₆H₁₅F₃N₂O₄
• Molekulatömeg: 356.30
• UNSPSC kód: 12352200

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• form: solid
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; protect from light
• szín: yellow
• oldhatóság: DMSO: 35 mg/mL; ethanol: 35 mg/mL
• tárolási hőmérséklet: 2-8°C

Leírás

Általános leírás

A synthetic dihydropyridine derivative that is an active Ca²⁺ slow channel agonist in neuroendocrine, muscle, thyroid, and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca²⁺ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive ionotropic, and Ca²⁺ agonistic properties, whereas the (+)-enantiomer has weak vasodilating, negative ionotropic, and Ca²⁺ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.

Synthetic dihydropyridine derivative that acts as an active Ca²⁺ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca²⁺ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive inotropic, and Ca²⁺ agonistic properties, whereas the (+)-enantiomer has weakly vasodilating, negative inotropic, and Ca²⁺ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.

Biokémiai/fiziológiai hatások

Primary Target
L-type Ca2+ channel

Figyelmeztetés

Toxicity: Irritant (B)

Feloldás

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.

Egyéb megjegyzések

Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA106, 1427.
Weigl, L.G., et al. 2000. J. Physiol.525 (pt. 2), 461.
Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun.143, 1107.
Tagliatela, M., et al. 1986. Brain Res.381, 356.
Franckowiak, G., et al. 1985. Eur. J. Pharmacol.114, 223.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable