124015

Akt Inhibitor IV

InSolution, ≥98%

• Szinonimák: InSolution Akt Inhibitor IV
• Tapasztalati képlet (Hill-képlet): C₃₁H₂₇IN₄S
• Molekulatömeg: 614.54
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• Forma: liquid
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; desiccated (hygroscopic); protect from light
• kiszállítva: wet ice
• tárolási hőmérséklet: 2-8°C

Leírás

Általános leírás

A cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activation presumably by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC₅₀ = 625 nM) and cell proliferation (IC₅₀<1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K.

Biokémiai/fiziológiai hatások

Cell permeable: yes

Primary Target
Akt

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 625 nM and <1.25 µM in blocking Akt-mediated FOXO1a nuclear export and cell proliferation, respectively, in 786-O cells

Kiszerelés

Packaged under inert gas

Please refer to vial label for lot-specific concentration.

Figyelmeztetés

Toxicity: Irritant (B)

Fizikai forma

A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124011) in DMSO.

Feloldás

Following initial use, aliquot and refrigerate (4°C).

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 2
• Lobbanási pont (F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Lobbanási pont (C): 87 °C - closed cup - (Dimethylsulfoxide)