124009
Akt Inhibitor III
The Akt Inhibitor III controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Szinonimák:
Akt Inhibitor III, SH-6
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Tapasztalati képlet (Hill-képlet):
C28H57O9P
Molekulatömeg:
568.72
UNSPSC kód:
12352200
NACRES:
NA.77
Javasolt termékek
Minőségi szint
Teszt
≥98% (NMR)
form
solid
gyártó/kereskedő neve
Calbiochem®
tárolási körülmény
OK to freeze
szín
white
oldhatóság
DMSO: 10 mg/mL
kiszállítva
ambient
tárolási hőmérséklet
−20°C
Általános leírás
A cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and select downstream substrates without decreasing phosphorylation of PDK-1 or other kinases downstream of Ras, such as MAPK. Also acts as a potent inducer of apoptosis and selectively kills a variety of cancer cell lines that contain high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit PKA activity.
A phosphatidylinositol analog that inhibits the activation of Akt and selected downstream substrates without affecting the phosphorylation of PDK-1 and other downstream kinases. Decreases phosphorylation of Akt without affecting the total Akt level. Reported to be a potent inducer of apoptosis and to selectively kill a variety of cancer cell lines expressing high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit PKA activity.
Biokémiai/fiziológiai hatások
Cell permeable: yes
Primary Target
Akt
Akt
Product does not compete with ATP.
Reversible: yes
Kiszerelés
Packaged under inert gas
Figyelmeztetés
Toxicity: Standard Handling (A)
Feloldás
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Egyéb megjegyzések
Gills, J.J., et al. 2007. J. Biol. Chem.in press.
Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.
Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.
Jogi információk
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 1
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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