05-1570

Anti-PRDM1 (BLIMP-1) Antibody, clone 6D3

clone 6D3, from rat

• Szinonimák: PR domain containing 1, with ZNF domain, PR-domain zinc finger protein 1, beta-interferon gene positive-regulatory domain I binding factor, Positive regulatory domain I-binding factor 1, PRDI-binding factor-1, Beta-interferon gene positive regulatory dom
• UNSPSC kód: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• klón: 6D3, monoclonal
• application: ELISA; FACS; IHC; WB
• faj reaktivitás: mouse, human
• technika/technikák: ELISA: suitable; flow cytometry: suitable; immunohistochemistry: suitable; western blot: suitable

Tulajdonságok

• biológiai forrás: rat
• Minőségi szint: 100
• antitest forma: purified immunoglobulin
• antitest terméktípus: primary antibodies
• klón: 6D3, monoclonal
• faj reaktivitás: mouse, human
• technika/technikák: ELISA: suitable; flow cytometry: suitable; immunohistochemistry: suitable; western blot: suitable
• izotípus: IgG2aκ
• NCBI elérési szám: NP_031574
• UniProt elérési szám: Q60636
• kiszállítva: wet ice
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... PRDM1(639)

Leírás

Általános leírás

B-lymphocyte induced maturation protein (BLIMP-1) is a 100 kDa transcriptional repressor containing 1 DET domain and 4 C2H2-type zinc fingers. In the nucleus, BLIMP-1 is known to bind specifically with the Beta-interferon gene positive regulatory domain I (PRDI), and to interact with PRMT5. During B-cell differentiation, BLIMP-1 actively represses the transcription of the gene, c-myc, through binding its promoter and has been deemed a “master regulator” for terminal B-cell differentiation, as it is able to initiate the BCL1 cell developmental cascade.

Egyediség

Recognizes BLIMP-1

Immunogén

Epitope: Recognizes epitope located between amino acids 255-395 of BLIMP-1

Recombinant protein corresponding to mouse BLIMP-1.

Alkalmazás

ELISA Analysis: A representative lot was used by an independent laboratory in ELISA. (Kallies, A., et al. (2004). J Exp Med. 200(8):967-977.)

Flow Cytometry Analysis: A representative lot was used by an independent laboratory in FC. (Kallies, A., et al. (2004). J Exp Med. 200(8):967-977.)

Research Category
Epigenetics & Nuclear Function

Inflammation & Immunology

Use Anti-PRDM1 (BLIMP-1) Antibody, clone 6D3 (Rat Monoclonal Antibody) validated in WB, ELISA, IHC, FC to detect PRDM1 (BLIMP-1) also known as PR-domain zinc finger protein 1.

Minőség

Evaluated by Western Blot in HL-60 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected BLIMP-1 on 10 µg of HL-60 cell lysate.

Cél megnevezése

~ 95 kDa observed

Fizikai forma

Format: Purified

Egyéb megjegyzések

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Biztonsági adatok

• Tárolási osztály kódja: 12 - Non Combustible Liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable