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Merck
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D-013

Supelco

Dextromethorphan solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)

About This Item

Tapasztalati képlet (Hill-képlet):
C18H25NO
CAS-szám:
125-71-3
Molekulatömeg:
271.40
MDL-szám:
MFCD00866833
UNSPSC kód:
41116107
PubChem Substance ID:
329798586
NACRES:
NA.24

grade

certified reference material

Minőségi szint

300

form

liquid

Jellemzők

Snap-N-Spike®/Snap-N-Shoot®

kiszerelés

ampule of 1 mL

gyártó/kereskedő neve

Cerilliant®

koncentráció

1.0 mg/mL in methanol

technika/technikák

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

alkalmazás(ok)

forensics and toxicology

format

single component solution

tárolási hőmérséklet

−20°C

SMILES string

COc1ccc2C[C@H]3[C@H]4CCCC[C@@]4(CCN3C)c2c1

InChI

1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1

Nemzetközi kémiai azonosító kulcs

MKXZASYAUGDDCJ-NJAFHUGGSA-N

Géninformáció

human ... GRIN2A(2903) , SIGMAR1(10280)

Általános leírás

Dextromethorphan is an opiate analgesic sold as an antitussive under trade names such as Robitussin®, NyQuil®, or Dimetapp®. Also known as DXM, the drug is used recreationally as a hallucinogen with effects similar to ketamine and phencyclidine (PCP). This Certified Snap-N-Spike® Solution is suitable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications from forensic analysis and clinical toxicology to P450 trials and pharmaceutical research.

Alkalmazás


  • Voriconazole-D3 isotopic label: It is used to develop a method for the simultaneous determination of voriconazole and its metabolite, voriconazole N-oxide, in human urine using liquid chromatography/tandem mass spectrometry. This study highlights the application of voriconazole-D3 as a stable isotope-labeled internal standard, crucial for accurate quantification and monitoring of drug metabolism in clinical pharmacokinetic studies (Yu et al., 2022).


Jogi információk

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Dimetapp is a registered trademark of Wyeth LLC
NyQuil is a registered trademark of Procter & Gamble Co.
Robitussin is a registered trademark of Wyeth LLC
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Figyelmeztetés

Danger

Figyelmeztető mondatok

H225,H301 + H311 + H331,H370

Veszélyességi osztályok

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Célzott szervek

Eyes,Central nervous system

Tárolási osztály kódja

3 - Flammable liquids

WGK

WGK 2

Lobbanási pont (F)

51.8 °F - closed cup

Lobbanási pont (C)

11.0 °C - closed cup

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

Már rendelkezik ezzel a termékkel?

Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

G Nicholas Verne et al.
The journal of pain : official journal of the American Pain Society, 13(9), 901-909 (2012-09-11)
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder in which the pathophysiological mechanisms of the pain and hypersensitivity are incompletely understood. IBS patients frequently complain of pain in body regions somatotopically distinct from the gut, suggesting involvement of central
Andreas Trojan et al.
Cancer chemotherapy and pharmacology, 71(2), 301-306 (2012-10-27)
Endoxifen serum concentrations seem to correlate with outcome in breast cancer (BC) patients. Concurrently, cytochrome P450 2D6 (CYP2D6) enzyme activity and dextromethorphan (DM) metabolism are deemed a surrogate marker for the formation of endoxifen. Here, we conducted a matched cohort
Shiou-Lan Chen et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 7(4), 1025-1033 (2012-09-20)
Recent studies show that proinflammatory cytokines might be related to the development of opioid dependence (physiological, psychological, or both). In a double-blind, randomly stratified clinical trial investigating whether add-on dextromethorphan (60-120 mg/day) attenuated inflammation and the combined use of opioids
Muneaki Matsuo et al.
Pediatric neurology, 48(3), 200-205 (2013-02-20)
Acute encephalopathy with biphasic seizures and late reduced diffusion was recently established clinicoradiologically as an encephalopathy syndrome. The outcome of this encephalopathy is characterized by a low mortality rate and high incidence of neurologic sequelae. Although the exact pathogenesis of
F L Opdam et al.
Cancer chemotherapy and pharmacology, 71(3), 593-601 (2012-12-12)
Adjuvant therapy with tamoxifen significantly reduces breast cancer recurrence and mortality in estrogen receptor positive disease. CYP2D6 is the main enzyme involved in the activation of the prodrug tamoxifen into the anti-estrogen endoxifen. Endoxifen is thought to be a main
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