878110P

C16-02:0 PC

Avanti Research^™ - A Croda Brand 878110P, powder

• Szinonimák: 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine
• Tapasztalati képlet (Hill-képlet): C₂₆H₅₄NO₇P
• CAS-szám: 74389-68-7
• Molekulatömeg: 523.68
• UNSPSC kód: 12352211
• NACRES: NA.25

Tulajdonságok

• form: powder
• kiszerelés: pkg of 1 × 25 mg (878110P-25mg); pkg of 1 × 5 mg (878110P-5mg)
• gyártó/kereskedő neve: Avanti Research^™ - A Croda Brand 878110P
• lipidtípus: phosphoglycerides; bioactive lipids
• kiszállítva: dry ice
• tárolási hőmérséklet: −20°C
• SMILES string: [O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(C)=O)COCCCCCCCCCCCCCCCC)=O
• InChI: 1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1
• Nemzetközi kémiai azonosító kulcs: HVAUUPRFYPCOCA-AREMUKBSSA-N

Leírás

Általános leírás

C16-02:0 PC, also referred as 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (C16 PAF) (acetyl PAF), is a platelet-activating factor (PAF). Acetyl PAF is a natural PAF with ether-linked hexadecyl chain at the sn-1 position and an acetyl group at the sn-2 position.

Alkalmazás

C16-02:0 PC or 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine may be used as a substrate in enzymatic lipoprotein-associated phospholipase A2 (Lp-PLA2) activity assay. It may also be used to study its physicochemical properties and its interaction with peptides derived from the C-terminal domains of human apolipoprotein E.

Biokémiai/fiziológiai hatások

C16-02:0 PC, a platelet-activating factor and a lipid mediator is involved in various inflammatory diseases. It facilitates initiation and progression of atherosclerosis. PAF acts as a potential biomarker for coronary artery diseases. It exhibits its activity by binding to a specific PAF receptor, which belongs to the seven transmembrane-spanning G-protein-linked receptors family. PAF on hydrolysis by platelet-activating factor-acetyl hydrolase produces LysoPAF (1-O-alkyl-2-hydroxy-sn-glycero-3-phosphocholine).

Kiszerelés

5 mL Clear Glass Sealed Ampule (878110P-25mg)

5 mL Clear Glass Sealed Ampule (878110P-5mg)

Jogi információk

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable