Přejít k obsahu
Merck
Všechny fotografie(4)

Key Documents

View All Documentation

S8751

Sigma-Aldrich

Sulfaguanidine

Synonyma:

4-Amino-N-(aminoiminomethyl)benzenesulfonamide, 4-Amino-N-guanylbenzenesulfonamide

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
Všechny fotografie(4)

About This Item

Empirický vzorec (Hillův zápis):
C7H10N4O2S
Číslo CAS:
57-67-0
Molekulová hmotnost:
214.24
Beilstein/REAXYS Number:
2695326
EC Number:
200-345-9
MDL number:
MFCD00038136
UNSPSC Code:
51283914
PubChem Substance ID:
24899810
NACRES:
NA.85

biological source

synthetic (Organic)

form

powder

color

white to off-white

solubility

1 M HCl: soluble 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

DNA synthesis | interferes
enzyme | inhibits

SMILES string

NC(=N)NS(=O)(=O)c1ccc(N)cc1

InChI

1S/C7H10N4O2S/c8-5-1-3-6(4-2-5)14(12,13)11-7(9)10/h1-4H,8H2,(H4,9,10,11)

InChI key

BRBKOPJOKNSWSG-UHFFFAOYSA-N

Gene Information

human ... F2(2147) , PRSS1(5644)

Hledáte podobné produkty? Navštivte Průvodce porovnáváním produktů

Související kategorie

General description

Chemical structure: sulfonamide

Application

Sulfaguanidine is used to block the synthesis of folic acid. It is used to study its effect on microsporidial growth and host cell viability.

Biochem/physiol Actions

Sulfaguanidine is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. Sulfaguanidine is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Osvědčení o analýze (COA)

Vyhledejte osvědčení Osvědčení o analýze (COA) zadáním čísla šarže/dávky těchto produktů. Čísla šarže a dávky lze nalézt na štítku produktu za slovy „Lot“ nebo „Batch“.

Již tento produkt vlastníte?

Dokumenty související s produkty, které jste v minulosti zakoupili, byly za účelem usnadnění shromážděny ve vaší Knihovně dokumentů.

Navštívit knihovnu dokumentů

Zákazníci si také prohlíželi

Slide 1 of 4

1 of 4

Sulfamethoxypyridazine VETRANAL®, analytical standard

Supelco

46858

Sulfamethoxypyridazine

Sulfanilamide ≥98%

Sigma-Aldrich

S9251

Sulfanilamide

Sulfisoxazole VETRANAL®, analytical standard

Supelco

31739

Sulfisoxazole

Terfenadine

Sigma-Aldrich

T9652

Terfenadine

Alan D Gift et al.
Journal of pharmaceutical and biomedical analysis, 43(1), 14-23 (2006-08-03)
A moisture sorption gravimetric analyzer has been combined with a Raman spectrometer to better understand the various modes of water-solid interactions relevant to pharmaceutical systems. A commercial automated moisture sorption balance was modified to allow non-contact monitoring of the sample
T W Wong et al.
Journal of microencapsulation, 19(4), 511-522 (2002-10-25)
The potential application of pectin as a matrix polymer for making microspheres by an emulsification technique was explored, and the drug release property of these pectinate microspheres containing drug cores of varying aqueous solubilities: sulphanilamide, sulphaguanidine and sulphathiazole, was investigated
K Nakanishi et al.
Journal of pharmacobio-dynamics, 13(12), 760-765 (1990-12-01)
The influence of suppository bases and adjuvants on the release rate of drugs and the absorption of non-absorbable drugs such as sulfanilic acid (SA) and sulfaguanidine (SG), was investigated following the rectal administration of suppositories. The suppository bases used were
Carmen M Sharaby
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 62(1-3), 326-334 (2005-11-01)
Novel hexachlorocyclodiphosph(V)azane of sulfaguanidine, H(4)L, l,3-[N'-amidino-sulfanilamide]-2,2,2,4,4,4-hexachlorocyclodiphosph(V)azane was prepared and its coordination behaviour towards the transition metal ions Fe(III), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and UO(2)(II) was studied. The structures of the isolated products are proposed based on elemental analyses
Erythema multiforme from sulfaguanidine.
Consolación de Frutos et al.
Contact dermatitis, 46(3), 186-187 (2002-05-10)
Zobrazit všechny související dokumenty

Náš tým vědeckých pracovníků má zkušenosti ve všech oblastech výzkumu, včetně přírodních věd, materiálových věd, chemické syntézy, chromatografie, analytiky a mnoha dalších..

Obraťte se na technický servis.