900755

SLAP TA

95%

• Synonyma: 3-(((Trimethylsilyl)methyl)thio)propan-1-amine
• Empirický vzorec (Hillův zápis): C₇H₁₉NSSi
• Číslo CAS: 2093935-86-3
• Molekulová hmotnost: 177.38
• UNSPSC Code: 12352103
• NACRES: NA.22

Vlastnosti

• Quality Level: 100
• assay: 95%
• form: liquid
• density: 0.90452
• storage temp.: 2-8°C

Popis

Application

When used with aliphatic or aromatic aldehydes, this silicon amine protocol SLAP reagent enables the photomediated synthesis of thiomorpholines and thiazepanes. For photocatalytic cross-coupling with this SLAP Reagent, Ir[(ppy)₂dtbbpy]PF₆ (747769) is used with a recommended starting combination of Lewis acids Bi(OTf)₃ (633305) and Cu(OTf)₂ (283673) prior to subsequent substrate-specific optimization. This product was introduced in collaboration with the Bode Research Group and provides a tin-free alternative to SnAP (tin amine protocol) reagents and is well-suited for scale-up reactions.

Other Notes

• Technology Spotlight: SLAP Reagents for Piperazine Synthesis
• Silicon Amine Reagents for the Photocatalytic Synthesis of Piperazines from Aldehydes and Ketones
• Lewis Acid Induced Toggle from Ir(II) to Ir(IV) Pathways in Photocatalytic Reactions: Synthesis of Thiomorpholines and Thiazepanes from Aldehydes and SLAP Reagents.
• Continuous Flow Synthesis of Morpholines and Oxazepanes with Silicon Amine Protocol (SLAP) Reagents and Lewis Acid Facilitated Photoredox Catalysis

Bezpečnostní informace

• pictograms: GHS02
• signalword: Warning
• hcodes: H226
• pcodes: P210 - P370 + P378
• Hazard Classifications: Flam. Liq. 3
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 75.0 °F
• flash_point_c: 23.89 °C