281778

(3-Aminopropyl)trimethoxysilane

97%

• Synonyma: 3-(Trimethoxysilyl)propylamine
• Lineární vzorec: H₂N(CH₂)₃Si(OCH₃)₃
• Číslo CAS: 13822-56-5
• Molekulová hmotnost: 179.29
• UNSPSC Code: 12352103
• NACRES: NA.23
• PubChem Substance ID: 24856993
• EC Number: 237-511-5
• Beilstein/REAXYS Number: 2038118
• MDL number: MFCD00008206

Vlastnosti

• Quality Segment: 200
• assay: 97%
• form: liquid
• refractive index: n20/D 1.424 (lit.)
• bp: 91-92 °C/15 mmHg (lit.)
• density: 1.027 g/mL at 25 °C (lit.)
• functional group: silyl
• SMILES string: CO[Si](CCCN)(OC)OC
• InChI: 1S/C6H17NO3Si/c1-8-11(9-2,10-3)6-4-5-7/h4-7H2,1-3H3
• InChI key: SJECZPVISLOESU-UHFFFAOYSA-N

Popis

General description

(3-Aminopropyl)trimethoxysilane (APTMS) is a high-reactivity aminosilane engineered for the deposition of cationic Self-Assembled Monolayers (SAMs) on inorganic substrates. Its trimethoxy structure ensures faster hydrolysis and denser surface grafting compared to ethoxy-silanes, providing a terminal primary amine (-NH2) handle for the covalent attachment of biomolecules, polymers, and fluorophores. Beyond biotechnology, APTMS is a pivotal interfacial modifier in nanoelectronics, where it passivates dielectric surfaces to enhance charge-carrier mobility in organic field-effect transistors (OFETs) and enables the precise alignment of carbon nanotubes and graphene. Refined to a 97% high-purity specification, this grade is engineered to provide excellent consistency for applications requiring precise and reliable surface functionalization.

Application

As a versatile molecular bridge, APTMS is essential for engineering intelligent interfaces and stimuli-responsive systems that enable precise interactions at the intersection of nanotechnology, biology, and electronics.

Stimuli-Responsive Nanocarriers: Functionalizes mesoporous silica pores to create pH-sensitive "gatekeepers" that trigger drug release specifically within acidic tumor microenvironments.

Gene & Nucleic Acid Delivery: Modulates the surface zeta potential of nanoparticles to facilitate high-efficiency electrostatic loading and endosomal escape of siRNA, mRNA, and pDNA.

Precision Bioconjugation: Acts as a molecular bridge for anchoring targeting ligands (e.g., Folate, RGD peptides) or PEG chains to gold and iron oxide nanoparticles for enhanced circulation and cell-specific uptake.

Advanced Biosensing: Utilized in LSPR-based diagnostics to immobilize antibodies onto gold nanostructures, enabling real-time detection of clinical biomarkers such as C-reactive protein (CRP).

Neuro-Targeting: Recent findings highlight its role in tuning nanoparticle surface charge to improve Blood-Brain Barrier (BBB) permeability via adsorptive-mediated transcytosis

Packaging

Optically tunable core-shell composite nanorod structures have been prepared by depositing gold onto silica and titania nanorods which have been surface modified with (3-Aminopropyl)trimethoxysilane

Bezpečnostní informace

• Piktogramy: GHS05
• Výstražné slovo: Danger
• Kódy nebezpečí: H315,H318
• Bezpečnostní pokyny: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P362 + P364
• Hazard Classifications: Eye Dam. 1 - Skin Irrit. 2
• Skladovací třída: 10 - Combustible liquids
• Bod vzplanutí (°F): 188.6 °F - closed cup
• Bod vzplanutí (°C): 87 °C - closed cup
• PPE (osobní ochranné prostředky): Eyeshields, Gloves, type ABEK (EN14387) respirator filter